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(+)-Kavain
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Catalog No. T4590Cas No. 500-64-1
Alias L-KAWAIN, Kavain, (R)-KAWAIN
(+)-Kavain ((R)-KAWAIN) is one of the six major kavalactones found in the Piper methysticum (kava) plant; reversible inhibitor of MAO-B.
(+)-Kavain
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Purity: 99.92%
Catalog No. T4590Alias L-KAWAIN, Kavain, (R)-KAWAINCas No. 500-64-1
(+)-Kavain ((R)-KAWAIN) is one of the six major kavalactones found in the Piper methysticum (kava) plant; reversible inhibitor of MAO-B.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | $40 | In Stock | In Stock | |
| 25 mg | $68 | In Stock | In Stock | |
| 50 mg | Preferential | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $30 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.92%
Color:White
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Product Introduction
(+)-Kavain AI Summary
(+)-Kavain exhibits a broad spectrum of bioactivities. It inhibits TNF-alpha-induced NF-kappaB expressed in human A549 cells with an IC50 value of 32.0 µg/mL and demonstrates hepatotoxicity against mouse Hepa-1c1c7 cells with an IC50 value of 166.0 µg/mL after 48 hours. Additionally, it induces the erasure of genomic imprints, inhibits aldehyde dehydrogenase 1 (ALDH1A1), modulates lipid storage in Drosophila S3 cells, and inhibits AmpC beta-lactamase. It also has notable effects on inhibiting chronic active B-cell receptor signaling, inducing genotoxicity, and affecting various signaling pathways including retinoid X receptor alpha, peroxisome proliferator-activated receptor delta, and the antioxidant response element. The compound shows antifungal activity against species like Fusarium oxysporum, Fusarium solani, and Colletotrichum gloeosporioides, as well as herbicidal activity against Echinochloa crus-galli and Lactuca sativa cv. Great Lakes 366. Moreover, (+)-Kavain exhibits moderate antiviral activity against SARS-CoV-2, with an IC50 value greater than 20000.0 nM in VERO-6 cells, indicating inhibition of virus-induced cytotoxicity at 10 µM concentration. This spectrum of activity underscores its potential in various biological applications..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | (+)-Kavain ((R)-KAWAIN) is one of the six major kavalactones found in the Piper methysticum (kava) plant; reversible inhibitor of MAO-B. |
| Synonyms | L-KAWAIN, Kavain, (R)-KAWAIN |
| Molecular Weight | 230.26 |
| Formula | C14H14O3 |
| Cas No. | 500-64-1 |
| Smiles | COC1=CC(=O)O[C@H](C1)\C=C\c1ccccc1 |
| Relative Density. | 1.15 g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 45 mg/mL (195.43 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.69 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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