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Tesmilifene fumarate

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Catalog No. T22746Cas No. 1185241-83-1
Alias DPPE fumarate

Tesmilifene fumarate (DPPE fumarate) (DPPE fumarate) is an H1C receptor antagonist.

Tesmilifene fumarate
Other Forms of Tesmilifene fumarate:

Tesmilifene fumarate

🥰Excellent
Purity: 99.86%
Catalog No. T22746Alias DPPE fumarateCas No. 1185241-83-1
Tesmilifene fumarate (DPPE fumarate) (DPPE fumarate) is an H1C receptor antagonist.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$39In StockIn Stock
10 mg$58In StockIn Stock
25 mg$118In StockIn Stock
50 mg$176In StockIn Stock
100 mg$262In StockIn Stock
200 mg$388-In Stock
1 mL x 10 mM (in DMSO)$44In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.86%
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Product Introduction

Bioactivity
Description
Tesmilifene fumarate (DPPE fumarate) (DPPE fumarate) is an H1C receptor antagonist.
In vitro
Tesmilifene may indirectly modulate the effects of 12(S)-HETE in cancer cells, influencing the susceptibility of cellular DNA to chemotherapy[1].
In vivo
Tesmilifene (DPPE, 20 mg/kg (s.c.) and 20 μg (icv in 5 μL)) potentiated seizures induced by both convulsants[2].
SynonymsDPPE fumarate
Chemical Properties
Molecular Weight399.48
FormulaC23H29NO5
Cas No.1185241-83-1
SmilesOC(=O)\C=C\C(O)=O.CCN(CC)CCOc1ccc(Cc2ccccc2)cc1
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 248 mg/mL (620.81 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (12.52 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5033 mL12.5163 mL25.0325 mL125.1627 mL
5 mM0.5007 mL2.5033 mL5.0065 mL25.0325 mL
10 mM0.2503 mL1.2516 mL2.5033 mL12.5163 mL
20 mM0.1252 mL0.6258 mL1.2516 mL6.2581 mL
50 mM0.0501 mL0.2503 mL0.5007 mL2.5033 mL
100 mM0.0250 mL0.1252 mL0.2503 mL1.2516 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Tesmilifene FumarateTesmilifene fumarateTesmilifeneseizureInhibitorinhibitHistamineReceptorHistamine ReceptorDPPE FumarateDPPEchemotherapyanti-histaminic
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