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Tesmilifene fumarate

Name: Tesmilifene fumarate
Brand: TargetMol
SKU: T22746
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22746Cas No. 1185241-83-1

Alias DPPE fumarate

Tesmilifene fumarate (DPPE fumarate) (DPPE fumarate) is an H1C receptor antagonist.

Tesmilifene fumarate

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Purity: 99.86%

Catalog No. T22746Alias DPPE fumarateCas No. 1185241-83-1

Tesmilifene fumarate (DPPE fumarate) (DPPE fumarate) is an H1C receptor antagonist.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$39	In Stock	In Stock
10 mg	$58	In Stock	In Stock
25 mg	$118	In Stock	In Stock
50 mg	$176	In Stock	In Stock
100 mg	$262	In Stock	In Stock
200 mg	$388	-	In Stock
1 mL x 10 mM (in DMSO)	$44	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.86%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Tesmilifene fumarate (DPPE fumarate) (DPPE fumarate) is an H1C receptor antagonist.
In vitro	Tesmilifene may indirectly modulate the effects of 12(S)-HETE in cancer cells, influencing the susceptibility of cellular DNA to chemotherapy[1].
In vivo	Tesmilifene (DPPE, 20 mg/kg (s.c.) and 20 μg (icv in 5 μL)) potentiated seizures induced by both convulsants[2].
Synonyms	DPPE fumarate

Chemical Properties

Molecular Weight	399.48
Formula	C₂₃H₂₉NO₅
Cas No.	1185241-83-1
Smiles	OC(=O)\C=C\C(O)=O.CCN(CC)CCOc1ccc(Cc2ccccc2)cc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 248 mg/mL (620.81 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (12.52 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5033 mL	12.5163 mL	25.0325 mL	125.1627 mL
5 mM	0.5007 mL	2.5033 mL	5.0065 mL	25.0325 mL
10 mM	0.2503 mL	1.2516 mL	2.5033 mL	12.5163 mL
20 mM	0.1252 mL	0.6258 mL	1.2516 mL	6.2581 mL
50 mM	0.0501 mL	0.2503 mL	0.5007 mL	2.5033 mL
100 mM	0.0250 mL	0.1252 mL	0.2503 mL	1.2516 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc