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Nifenazone

Name: Nifenazone
Brand: TargetMol
SKU: T0980
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0980Cas No. 2139-47-1

Alias Nicodone, Nicazane, Niapyrin

Nifenazone (Nicodone) is a pyrazole drug, used in the in the treatment of rheumatic disorders.

Nifenazone

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Purity: 99.74%

Catalog No. T0980Alias Nicodone, Nicazane, NiapyrinCas No. 2139-47-1

Nifenazone (Nicodone) is a pyrazole drug, used in the in the treatment of rheumatic disorders.

Pack Size	Price	USA Warehouse	Global Warehouse
100 mg	$29	In Stock	In Stock
200 mg	$39	In Stock	In Stock
500 mg	$64	In Stock	In Stock
1 g	$94	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.74%

Appearance:Solid

Color:White

Resource Download

COA LCMS HPLC HNMR

Product Introduction

Nifenazone AI Summary

Nifenazone exhibits a diverse range of bioactivities across multiple assays. It shows potency in inhibiting various targets, including Menin-MLL interaction, Lamin A splicing, Tyrosyl-DNA phosphodiesterase, DNA Polymerase Beta, GCN5L2, ELG1-dependent DNA repair, malarial parasite plastid, USP1/UAF1, ATXN expression, Human Apurinic/apyrimidinic Endonuclease 1 (APE1), and PTHR. Additionally, it affects cell viability in various cancer cell lines such as HT-29, DLD-1, HCT116, SNU-C1, SW480, RKO, and Colo320. The compound shows high inhibitory activity in sodium fluorescein uptake assays in OATP1B1 and OATP1B3-transfected CHO cells, with inhibition percentages of 96.39% and 120.65%, respectively. However, its antiviral activity against SARS-CoV-2 appears limited, with low inhibition indices and minimal cytotoxicity reduction in infected Vero E6 and Caco-2 cells. Specifically, it inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 cells by 4.38% at 10 µM after 48 hours and shows 11.13% inhibition of SARS-CoV-2 3CL-Pro protease activity at 20 µM. In VERO-6 cells, the inhibition rate observed is -0.24% after 48 hours at the same concentration. Moreover, Nifenazone inhibits human HDAC6 activity by 13.09% in enzymatic assays. Despite a broad spectrum of potential targets and moderate activities, it did not exhibit significant activity (AC50 > 30000.0 nM) in several tested assays, indicating variable efficacy across different bioactivities..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Nifenazone (Nicodone) is a pyrazole drug, used in the in the treatment of rheumatic disorders.
Synonyms	Nicodone, Nicazane, Niapyrin

Chemical Properties

Molecular Weight	308.33
Formula	C₁₇H₁₆N₄O₂
Cas No.	2139-47-1
Smiles	Cc1c(NC(=O)c2cccnc2)c(=O)n(-c2ccccc2)n1C
Relative Density.	1.33g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 5.45 mg/mL (17.68 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (3.24 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2433 mL	16.2164 mL	32.4328 mL	162.1639 mL
5 mM	0.6487 mL	3.2433 mL	6.4866 mL	32.4328 mL
10 mM	0.3243 mL	1.6216 mL	3.2433 mL	16.2164 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc