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Glycylglycine

Name: Glycylglycine
Brand: TargetMol
SKU: T5286
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5286Cas No. 556-50-3

Alias N-Glycylglycine, Gly-gly, Glycyl-glycine, Glycine dipeptide, Diglycocoll, Diglycine

Glycylglycine (Diglycine) is a dipeptide used in biochemical research. It is the simplest of all dipeptides and is used as a starting template for preparation of more complex peptides. Glycine is involved in the body's production of DNA, phospholipids, and collagen, and in the release of energy.

Glycylglycine

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Catalog No. T5286Alias N-Glycylglycine, Gly-gly, Glycyl-glycine, Glycine dipeptide, Diglycocoll, DiglycineCas No. 556-50-3

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 g	$29	-	In Stock
1 mL x 10 mM (in H2O)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:≥95%

Appearance:solid

Color:White

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COA HNMR

Product Introduction

Glycylglycine AI Summary

Glycylglycine, with a measured partition coefficient (logP) value of 3.81, is likely to be lipophilic, suggesting a higher affinity for lipid-rich regions in biological systems, which could influence its bioavailability, distribution, and metabolism. It inhibits the human intestinal peptide carrier (PEPT1) with a Ki value of 1,000,000 nM and exhibits an IC50 value of 7244359.6 nM against Angiotensin I converting enzyme, indicating potential anti-hypertensive effects. Despite low binding affinity to PEPT1 (Ki = 1,000,000 nM) in human Caco-2 cells, it shows significant bioactivity in human PEPT1 expressed in MDCK cells with an EC50 value of 480,000 nM for activation and a max activation of 112.0% relative to Gly-Sar. The compound also demonstrates binding affinity to human PepT2 in SKTP cells with Ki values around 54,000 nM, and inhibits Gly-Sar uptake in PEPT2-expressing LLC-PK1 cells (Ki = 42,000 nM). It inhibits uptake of VACV in PEPT1-expressing CHO cells by more than 80.0%. Furthermore, Glycylglycine acts as an agonist at the PSGR/OR51E2 receptor with an EC50 value of 11,000 nM in human Hana3A cells, suggesting its potential bioactivity in modifying PSGR/OR51E2 receptor functions. Finally, it inhibits nitrogen-starved wild type sigma1278b yeast Gap1-mediated amino acid uptake by less than 15% at 5 mM after 60 seconds relative to L-citrulline..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Glycylglycine (Diglycine) is a dipeptide used in biochemical research. It is the simplest of all dipeptides and is used as a starting template for preparation of more complex peptides. Glycine is involved in the body's production of DNA, phospholipids, and collagen, and in the release of energy.
Synonyms	N-Glycylglycine, Gly-gly, Glycyl-glycine, Glycine dipeptide, Diglycocoll, Diglycine

Chemical Properties

Molecular Weight	132.12
Formula	C₄H₈N₂O₃
Cas No.	556-50-3
Smiles	NCC(=O)NCC(O)=O
Relative Density.	1.5851 g/cm3 (Estimated)
Sequence	H-Gly-Gly-OH
Sequence Short	GG

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: Insoluble

H2O: 10 mM, Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	7.5689 mL	37.8444 mL	75.6888 mL	378.4438 mL
5 mM	1.5138 mL	7.5689 mL	15.1378 mL	75.6888 mL
10 mM	0.7569 mL	3.7844 mL	7.5689 mL	37.8444 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc