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Anti-SIAE Antibody (6X555) is a Mouse antibody targeting SIAE. Anti-SIAE Antibody (6X555) can be used in IHC-P.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
100 μL | $198 | 7-10 days |
Description | Anti-SIAE Antibody (6X555) is a Mouse antibody targeting SIAE. Anti-SIAE Antibody (6X555) can be used in IHC-P. |
Alias | YSG2, sialic acid acetylesterase, LSE, CSE-C, CSEC, AIS6 |
Ig Type | Monoclonal Mouse IgG1 |
Clone | 6X555 |
Reactivity | Human |
Verified Activity | 1. Immunochemical staining of human SIAE in human prostate with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections). 2. Immunochemical staining of human SIAE in human colon carcinoma with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections). |
Application | IHC-P |
Recommended Dose | IHC-P: 1:50-1:200 |
Antibody Type | Monoclonal |
Host Species | Mouse |
Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human SIAE/sialate O-acetylesterase (rh SIAE/sialate O-acetylesterase; TMPY-02952; Q9HAT2-1; Met1-Lys523). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
Purification | Protein A |
Appearance | Liquid |
Formulation | 0.2 μm filtered solution in PBS |
Research Background | Sialate O-acetylesterase belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. It is widely expressed with high expression in the testis, prostate, and colon. The systematic name of this enzyme class is N-acyl-O-acetylneuraminate O-acetylhydrolase. Other names in common use include N-acetylneuraminate acetyltransferase, sialate 9(4)-O-acetylesterase, and sialidase. Sialate O-acetylesterase catalyzes the removal of O-acetyl ester groups from position 9 of the parent sialic acid, N-acetylneuraminic acid. Defects in Sialate O-acetylesterase are a cause of autoimmune disease type 6 (AIS6). Individuals manifesting susceptibility to autoimmune disease type 6 can suffer from juvenile idiopathic arthritis, rheumatoid arthritis, multiple sclerosis, Sjogren syndrome, systemic lupus erythematosus, type 1 diabetes, ulcerative colitis, and Crohn disease. |
Conjucates | Unconjugated |
Immunogen | Recombinant Human SIAE/sialate O-acetylesterase Protein (TMPY-02952) |
Antigen Species | Human |
Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
Transport | Shipping with blue ice. |
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