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Procodazole

Name: Procodazole
Brand: TargetMol
SKU: T0288
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0288Cas No. 23249-97-0

Alias Propazol, 2-Benzimidazolepropionic acid

Procodazole (2-Benzimidazolepropionic acid) is a non-specific active immunoprotective agent against viral and bacterial infections.

Procodazole

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Purity: 99.35%

Catalog No. T0288Alias Propazol, 2-Benzimidazolepropionic acidCas No. 23249-97-0

Procodazole (2-Benzimidazolepropionic acid) is a non-specific active immunoprotective agent against viral and bacterial infections.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
500 mg	$30	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.35%

Color:White

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COA LCMS HNMR

Product Introduction

Procodazole AI Summary

Procodazole has demonstrated a range of bioactivities and potential therapeutic applications. It inhibits the 8His-tagged Pin1 PPIase domain (45-163) with an IC50 value of 740,000 nM and shows significant antiproliferative activity against various human tumor cell lines with a GI50 value of 100,000 nM, with specific potency in ovarian cell line SK-OV-3 (GI50 of 236.59 nM). It also affects human cytoplasmic protein tyrosine phosphatases, showing a 3.0% increase in protein tyrosine phosphatase B and a 9.0% decrease in protein tyrosine phosphatase A activity under various pH conditions. The compound demonstrates antiviral properties by inhibiting SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells, although the inhibition rate is relatively low. In terms of enzyme modulation, Procodazole exhibits inhibitory activity against human HDAC6 and SARS-CoV-2 3CL-Pro protease, with observed inhibition of 10.58% and 12.33% respectively. Additionally, it shows agonist activity at the human recombinant phosphorylated AMPK complex, leading to 14% phosphorylation relative to AMP. Despite these activities, the compound generally displays weak bioactivity across various binding affinity assays with AC50 values greater than 30,000 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Procodazole (2-Benzimidazolepropionic acid) is a non-specific active immunoprotective agent against viral and bacterial infections.
Targets&IC50	CA IX:8.35 μM
Synonyms	Propazol, 2-Benzimidazolepropionic acid

Chemical Properties

Molecular Weight	190.2
Formula	C₁₀H₁₀N₂O₂
Cas No.	23249-97-0
Smiles	OC(=O)CCC1=NC2=CC=CC=C2N1
Relative Density.	1.367 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (315.46 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (10.52 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.2576 mL	26.2881 mL	52.5762 mL	262.8812 mL
5 mM	1.0515 mL	5.2576 mL	10.5152 mL	52.5762 mL
10 mM	0.5258 mL	2.6288 mL	5.2576 mL	26.2881 mL
20 mM	0.2629 mL	1.3144 mL	2.6288 mL	13.1441 mL
50 mM	0.1052 mL	0.5258 mL	1.0515 mL	5.2576 mL
100 mM	0.0526 mL	0.2629 mL	0.5258 mL	2.6288 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc