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NCT-505

Name: NCT-505
Brand: TargetMol
SKU: T12196
Price: 117 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12196Cas No. 2231079-74-4

NCT-505 is a potent and selective inhibitor of aldehyde dehydrogenase (ALDH1A1, IC50 = 7 nM) and a weak inhibitor of hALDH1A2, hALDH1A3, hALDH2, hALDH3A1 with IC50 values of >57 μM, 22.8 μM, 20.1 μM, and >57 μM, respectively.

NCT-505

🥰Excellent

Purity: 99.93%

Catalog No. T12196Cas No. 2231079-74-4

Pack Size	Price	Availability
1 mg	$117	In Stock
5 mg	$248	In Stock
10 mg	$371	In Stock
25 mg	$591	In Stock
50 mg	$798	In Stock
100 mg	$1,070	In Stock
200 mg	$1,430	In Stock
1 mL x 10 mM (in DMSO)	$285	In Stock

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Purity:99.93%

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COA LCMS

Product Introduction

Bioactivity

Description	NCT-505 is a potent and selective inhibitor of aldehyde dehydrogenase (ALDH1A1, IC50 = 7 nM) and a weak inhibitor of hALDH1A2, hALDH1A3, hALDH2, hALDH3A1 with IC50 values of >57 μM, 22.8 μM, 20.1 μM, and >57 μM, respectively.
Targets&IC50	ALDH1A2 (human):>57 μM , ALDH1A3 (human):22.8 μM , ALDH1A1:7 nM , ALDH2 (human):20.1 μM , ALDH3A1 (human):>57 μM
In vitro	NCT-505 (compound 86) is a potent and selective aldehyde dehydrogenase (ALDH1A1) inhibitor with IC50 of 7 nM, weakly inhibits hALDH1A2, hALDH1A3, hALDH2, hALDH3A1 (IC50s, >57, 22.8, 20.1, >57 μM ). NCT-505 has no significant inhibitory effect on 5-hydroxyprostaglandin dehydrogenase (HPGD) and type 4 hydroxysteroid dehydrogenase (HSD17β4) (IC50, >57 μM). In addition, NCT-505 showed potent cellular viability, reducing the viability of OV-90 cells with EC50 of 2.10-3.92 μM. NCT-505 is also cytotoxic to SKOV-3-TR cells with IC50 of 1, 3, 10, 20, 30 μM in titration analysis[1].

Chemical Properties

Molecular Weight	521.61
Formula	C₂₇H₂₈FN₅O₃S
Cas No.	2231079-74-4
Smiles	CS(=O)(=O)N1CCN(CC1)C(=O)c1cnc2ccc(F)cc2c1N1CCC(CC1)(C#N)c1ccccc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (105.44 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9171 mL	9.5857 mL	19.1714 mL	95.8571 mL
5 mM	0.3834 mL	1.9171 mL	3.8343 mL	19.1714 mL
10 mM	0.1917 mL	0.9586 mL	1.9171 mL	9.5857 mL
20 mM	0.0959 mL	0.4793 mL	0.9586 mL	4.7929 mL
50 mM	0.0383 mL	0.1917 mL	0.3834 mL	1.9171 mL
100 mM	0.0192 mL	0.0959 mL	0.1917 mL	0.9586 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc