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BET bromodomain inhibitor

Name: BET bromodomain inhibitor
Brand: TargetMol
SKU: T2072
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2072Cas No. 1505453-59-7

BET bromodomain inhibitor is a potent BET inhibitor.

BET bromodomain inhibitor

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🥰Excellent

Purity: 99.85%

Catalog No. T2072Cas No. 1505453-59-7

BET bromodomain inhibitor is a potent BET inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$32	In Stock	In Stock
2 mg	$45	In Stock	In Stock
5 mg	$73	In Stock	In Stock
10 mg	$123	In Stock	In Stock
25 mg	$208	In Stock	In Stock
50 mg	$293	In Stock	In Stock
100 mg	$463	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$80	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.85%

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

BET bromodomain inhibitor AI Summary

BET bromodomain inhibitor exhibits significant bioactivities by inhibiting the displacement of biotinylated tetra-acetylated histone H4 from the BRD4 bromodomain1 with an IC50 of 14.0 nM. It shows strong cytotoxicity against human MV4-11 cells, achieving a growth inhibition IC50 of 15.0 nM after 72 hours. Additionally, it effectively inhibits the binding of BRD4 BD142-168 to the biotinylated H4-tetraacetyl peptide, demonstrating IC50 values of 18.0 nM and 14.0 nM in the AlphaLisa Binding Assay. These results highlight the compound's high affinity and ability to interfere with the protein-peptide interaction of BRD4..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

BET bromodomain inhibitor is a potent BET inhibitor.

Chemical Properties

Molecular Weight	445.9
Formula	C₂₄H₂₀ClN₅O₂
Cas No.	1505453-59-7
Smiles	Cc1noc2[C@H](CC(N)=O)N=C(c3ccc(Cl)cc3)c3cc(ccc3-c12)-c1cnn(C)c1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (112.13 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.49 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2427 mL	11.2133 mL	22.4266 mL	112.1328 mL
5 mM	0.4485 mL	2.2427 mL	4.4853 mL	22.4266 mL
10 mM	0.2243 mL	1.1213 mL	2.2427 mL	11.2133 mL
20 mM	0.1121 mL	0.5607 mL	1.1213 mL	5.6066 mL
50 mM	0.0449 mL	0.2243 mL	0.4485 mL	2.2427 mL
100 mM	0.0224 mL	0.1121 mL	0.2243 mL	1.1213 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc