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CK2 inhibitor 2

Name: CK2 inhibitor 2
Brand: TargetMol
SKU: T35557
Price: 59 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T35557Cas No. 2641079-92-5

CK2 Inhibitor 2, characterized as a potent, selective, and orally active inhibitor of CK2, demonstrates an impressive IC50 value of 0.66 nM. It exhibits high selectivity towards Clk2 with an IC50 of 32.69 nM in comparison to CK2. Furthermore, CK2 Inhibitor 2 has been shown to possess promising antiproliferative and antitumor activities [1].

CK2 inhibitor 2

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Purity: 99.02%

Catalog No. T35557Cas No. 2641079-92-5

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$59	In Stock	In Stock
5 mg	$148	In Stock	In Stock
10 mg	$238	In Stock	In Stock
25 mg	$473	In Stock	In Stock
50 mg	$708	In Stock	In Stock
100 mg	$948	In Stock	In Stock
200 mg	$1,280	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$163	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.02%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	CK2 Inhibitor 2, characterized as a potent, selective, and orally active inhibitor of CK2, demonstrates an impressive IC50 value of 0.66 nM. It exhibits high selectivity towards Clk2 with an IC50 of 32.69 nM in comparison to CK2. Furthermore, CK2 Inhibitor 2 has been shown to possess promising antiproliferative and antitumor activities [1].
Targets&IC50	CK2:0.66 nM, CLK2/CK2:32.69 nM
In vitro	CK2 inhibitor 2 (compound 1c) effectively inhibits the proliferation of PC-3, HCT-116, MCF-7, HT-29, T24, and LO2 cancer cell lines with IC50 values of 4.53 μM, 3.07 μM, 7.50 μM, 5.18 μM, 6.10 μM, and 96.68 μM, respectively. It induces dose-dependent apoptosis in HCT-116 cells, achieving a 55% apoptotic ratio at 20 μM after 24 hours. The compound reduces phosphorylated Akt1 S129 and Cdc37 S13 expression, suggesting suppression of survival pathways. It also inhibits ALDH1A1 enzyme activity (IC50 of 0.10 μM) and downregulates its transcription and protein expression in HCT-116 cells, indicating potential for targeting cancer-specific metabolic pathways.
In vivo	Administering CK2 inhibitor 2 at doses ranging from 60 to 90 mg/kg orally, twice daily for four weeks, significantly inhibits tumor growth in a dose-dependent manner, achieving a peak inhibition rate of 69% at the 90 mg/kg dosage. A single oral dose of 25 mg/kg in Sprague-Dawley rats reveals pharmacokinetic parameters such as a maximum concentration (C max) of 7017.8 ng/mL, an elimination half-life (t 1/2) of 6.67 hours, and a clearance rate (CL) of 0.60 L/h/kg. The study utilized male BALB/c athymic nude mice, aged 5 weeks and weighing 16-18 grams, injected with HCT-116 cells, demonstrating dose-dependent tumor growth inhibition without noticeable changes in body weight.

Chemical Properties

Molecular Weight	392.84
Formula	C₂₁H₁₇ClN₄O₂
Cas No.	2641079-92-5
Smiles	N(C1=C2C(=C3C(=N1)C=C(C(NCCO)=O)C=C3)C=NC=C2)C4=CC(Cl)=CC=C4
Relative Density.	1.420 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (127.28 mM), Sonication and heating to 60℃ are recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2.5 mg/mL (6.36 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5456 mL	12.7278 mL	25.4557 mL	127.2783 mL
5 mM	0.5091 mL	2.5456 mL	5.0911 mL	25.4557 mL
10 mM	0.2546 mL	1.2728 mL	2.5456 mL	12.7278 mL
20 mM	0.1273 mL	0.6364 mL	1.2728 mL	6.3639 mL
50 mM	0.0509 mL	0.2546 mL	0.5091 mL	2.5456 mL
100 mM	0.0255 mL	0.1273 mL	0.2546 mL	1.2728 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc