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Anti-LIMPII/SR-B2 Antibody (7J773) is a Rabbit antibody targeting LIMPII/SR-B2. Anti-LIMPII/SR-B2 Antibody (7J773) can be used in IHC-P,ICC/IF.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
100 μL | 256 € | 7-10 days |
Description | Anti-LIMPII/SR-B2 Antibody (7J773) is a Rabbit antibody targeting LIMPII/SR-B2. Anti-LIMPII/SR-B2 Antibody (7J773) can be used in IHC-P,ICC/IF. |
Alias | SR-BII, scavenger receptor class B, member 2, LIMPII, LIMP-2, LGP85, HLGP85, EPM4, CD36L2, AMRF |
Ig Type | Monoclonal Rabbit IgG |
Clone | 7J773 |
Reactivity | Mouse |
Verified Activity | 1. Immunochemical staining of mouse SCARB2 in mouse kidney with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). 2. Immunochemical staining of mouse SCARB2 in mouse brain with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). 3. Immunofluorescence staining of mouse SCARB2 in mouse splenocytes. Cells were fixed with 4% PFA, blocked with 10% serum, and incubated with rabbit anti-mouse SCARB2 monoclonal antibody (1:60) at 4°C overnight. Then cells were stained with the Alexa Fluor® 488-conjugated Goat Anti-rabbit IgG secondary antibody (green) and counterstained with DAPI (blue). |
Application | IHC-P,ICC/IF |
Recommended Dose | IHC-P: 1:100-1:500; ICC-IF: 1:20-1:100 |
Antibody Type | Monoclonal |
Host Species | Rabbit |
Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse LIMP-2 / SCARB2 / CD36L2 (rM LIMP-2 / SCARB2 / CD36L2; TMPY-01434; NP_031670.1; Met1-Thr432). |
Purification | Protein A |
Appearance | Liquid |
Formulation | 0.2 μm filtered solution in PBS |
Research Background | Lysosomal Integral Membrane Protein II (LIMPII), also known as SCARB2, LPG85, and CD36L2, is a type I II multi-pass membrane glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes on all tissues and cell types so far examined. This protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. LIMPII is identified as a receptor for EV71 (human enterovirus species A, Enterovirus 71) and CVA16 (coxsackievirus A16) which are most frequently associated with hand, foot and mouth disease (HFMD). Expression of human LIMPII enables normally unsusceptible cell lines to support the viruses’ propagation and develop cytopathic effects. In addition, LIMPII also has been shown to bind thrombospondin-1, and may contribute to the pro-adhesive changes of activated platelets during coagulation, and inflammation. Deficiency of the protein in mice impairs cell membrane transport processes and causes pelvic junction obstruction, deafness, and peripheral neuropathy. |
Conjucates | Unconjugated |
Others Formats | APC/FITC/PE |
Antibody Types Available | 4 |
Immunogen | Recombinant Mouse LIMP-2 / SCARB2 / CD36L2 protein (TMPY-01434) |
Antigen Species | Mouse |
Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
Transport | Shipping with blue ice. |
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