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Anti-Jarid2 Antibody (2J289)
😃Good
Catalog No. TMAB-07862
Anti-Jarid2 Antibody (2J289) is a Rabbit antibody targeting Jarid2. Anti-Jarid2 Antibody (2J289) can be used in WB,ICC/IF.
Anti-Jarid2 Antibody (2J289)
Anti-Jarid2 Antibody (2J289)
😃Good
Catalog No. TMAB-07862
Anti-Jarid2 Antibody (2J289) is a Rabbit antibody targeting Jarid2. Anti-Jarid2 Antibody (2J289) can be used in WB,ICC/IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 μL | $149 | 7-10 days | 7-10 days | |
| 50 μL | $264 | 7-10 days | 7-10 days | |
| 100 μL | $470 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Jarid2 Antibody (2J289) is a Rabbit antibody targeting Jarid2. Anti-Jarid2 Antibody (2J289) can be used in WB,ICC/IF. |
| Ig Type | IgG |
| Clone | 2J289 |
| Reactivity | Human |
| Application | |
| Recommended Dose | WB: 1:500-2000; ICC/IF: 1:50-200 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus. Colocalizes with the PRC2 complex on chromatin. |
| Tissue Specificity | During embryogenesis, predominantly expressed in neurons and particularly in dorsal root ganglion cells. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| Research Background | Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis.Acts as an accessory subunit for the core PRC2 (Polycomb repressive complex 2) complex, which mediates histone H3K27 (H3K27me3) trimethylation on chromatin. |
| Immunogen | A synthesized peptide: human Jumonji |
| Antigen Species | Human |
| Gene Name | JARID2 |
| Gene ID | |
| Protein Name | Protein Jumonji |
| Uniprot ID | |
| Function | Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling. |
| Molecular Weight | Theoretical: 139 kDa. Actual: 139 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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