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Anti-VE-Cadherin Antibody-PE (2K899)
🥰Excellent
Catalog No. TMAY-00822P
Anti-VE-Cadherin Antibody-PE (2K899) is a PE-conjugated Mouse antibody targeting VE-Cadherin. Anti-VE-Cadherin Antibody-PE (2K899) can be used in FCM.
Anti-VE-Cadherin Antibody-PE (2K899)
Anti-VE-Cadherin Antibody-PE (2K899)
🥰Excellent
Catalog No. TMAY-00822P
Anti-VE-Cadherin Antibody-PE (2K899) is a PE-conjugated Mouse antibody targeting VE-Cadherin. Anti-VE-Cadherin Antibody-PE (2K899) can be used in FCM.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-VE-Cadherin Antibody-PE (2K899) is a PE-conjugated Mouse antibody targeting VE-Cadherin. Anti-VE-Cadherin Antibody-PE (2K899) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 2K899 |
| Reactivity | Human |
| Verified Activity | Flow cytometric analysis of Human CD144 expression on HUVEC cells. Cells were stained with PE-conjugated anti-Human CD144. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| Application | FCM |
| Recommended Dose | 5 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human VE-Cadherin / CD144 / CDH5 (rh VE-Cadherin / CD144 / CDH5; CAA56306.1; Met1-Gln593) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| Research Background | Cadherins (Calcium dependent adhesion molecules) are a class of transmembrane proteins. Cadherin-5, also known as VE-cadherin, CDH5 and CD144, an endothelial specific cell-cell adhesion molecule, plays a pivotal role in the formation, maturation and remodeling of the vascular wall. VE-Cadherin is widely considered to be specific for vascular endothelia in which it is either the sole or the predominant cadherin, often co-existing with N-cadherin. This specificity of VE-cadherin for vascular endothelial cells is important not only in blood and lymph vessel biology and medicine, but also for cell-type-based diagnoses, notably those of metastatic tumors. As a classical cadherin, VE-Cadherin links endothelial cells together by homophilic interactions mediated by its extracellular part and associates intracellularly with the actin cytoskeleton via catenins. Mechanisms that regulate VE-cadherin-mediated adhesion are important for the control of vascular permeability and leukocyte extravasation. In addition to its adhesive functions, VE-Cadherin regulates various cellular processes such as cell proliferation and apoptosis and modulates vascular endothelial growth factor receptor functions. Consequently, VE-cadherin is essential during embryonic angiogenesis. |
| Conjucates | PE |
| Others Formats | Unconjugated/APC/FITC |
| Antibody Types Available | 4 |
| Immunogen | Recombinant Human VE-Cadherin / CD144 / CDH5 Protein |
| Antigen Species | Human |
| Biology Area | Hemangioblast Markers, Cardiac Stem Cell Markers |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. |
| Transport | Shipping with blue ice. |
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