Anti-HDAC3 Antibody (6T538)

Name: Anti-HDAC3 Antibody (6T538)
Brand: TargetMol
SKU: TMAH-00536
Rating: 4.5 (1 reviews)

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Anti-HDAC3 Antibody (6T538) is an antibody targeting HDAC3. Anti-HDAC3 Antibody (6T538) can be used in ELISA,IHC,WB.

Anti-HDAC3 Antibody
(6T538)

Pack Size	Price	USA Stock	Global Stock	Quantity
50 μL	$208	7-10 days	7-10 days
100 μL	$348	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	Anti-HDAC3 Antibody (6T538) is an antibody targeting HDAC3. Anti-HDAC3 Antibody (6T538) can be used in ELISA,IHC,WB.
Ig Type	Rabbit IgG
Clone	6T538
Reactivity	Human

Application	ELISA IHC WB
Recommended Dose	WB:1:500-1:5000; IHC:1:50-1:200.
Antibody Type	Monoclonal
Subcellular Localization	Nucleus. Cytoplasm. Cytoplasm, cytosol.
Tissue Specificity	Widely expressed.
Construction	Recombinant Antibody
Purification	Affinity-chromatography
Appearance	Liquid
Formulation	Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Research Background	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation. Contributes, together with XBP1 isoform 1, to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to endothelial cell (EC) survival under disturbed flow/oxidative stress. Regulates both the transcriptional activation and repression phases of the circadian clock in a deacetylase activity-independent manner. During the activation phase, promotes the accumulation of ubiquitinated ARNTL/BMAL1 at the E-boxes and during the repression phase, blocks FBXL3-mediated CRY1/2 ubiquitination and promotes the interaction of CRY1 and ARNTL/BMAL1. The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver. Serves as a corepressor of RARA, causing its deacetylation and inhibition of RARE DNA element binding. In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response. Interacts with SETD5.

Related Conjugates and Formulations

Conjucates

Unconjugated

Antigen Details

Immunogen	A synthetic peptide: Human HDAC3
Antigen Species	Human
Gene Name	HDAC3
Gene ID	8841
Uniprot ID	O15379
Biology Area	Epigenetics and Nuclear Signaling, Cancer, Cardiovascular, Metabolism, Stem cells