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LY518674

Name: LY518674
Brand: TargetMol
SKU: T15821
Price: 179 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15821Cas No. 425671-29-0

Alias LY-674

LY518674 (LY-674) decreases triglycerides and increases HDL-C and is used for the treatment of atherosclerosis. LY518674 is an effective and selective PPARα agonist (EC50: 42 nM for human PPARα).

LY518674

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Purity: 98.87%

Catalog No. T15821Alias LY-674Cas No. 425671-29-0

LY518674 (LY-674) decreases triglycerides and increases HDL-C and is used for the treatment of atherosclerosis. LY518674 is an effective and selective PPARα agonist (EC50: 42 nM for human PPARα).

Pack Size	Price	Availability
1 mg	$179	In Stock
5 mg	$378	In Stock
10 mg	$562	In Stock
25 mg	$892	In Stock
50 mg	$1,220	In Stock
100 mg	$1,650	In Stock
1 mL x 10 mM (in DMSO)	$418	In Stock

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Batch Information

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Purity:98.87%

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COA HPLC HNMR LCMS

Product Introduction

Bioactivity

Description	LY518674 (LY-674) decreases triglycerides and increases HDL-C and is used for the treatment of atherosclerosis. LY518674 is an effective and selective PPARα agonist (EC50: 42 nM for human PPARα).
Targets&IC50	PPARα:42 nM (EC50 human)
In vivo	LY518674 decreases triglycerides and increased HDL-C in vivo[2]. LY518674 significantly enhances apolipoprotein A-I (apoA-I) turnover without a major impact on steady-state levels of apoA-I or high-density lipoprotein-cholesterol (HDL-C) [3].
Synonyms	LY-674

Chemical Properties

Molecular Weight	409.48
Formula	C₂₃H₂₇N₃O₄
Cas No.	425671-29-0
Smiles	Cc1ccc(Cn2[nH]c(CCCc3ccc(OC(C)(C)C(O)=O)cc3)nc2=O)cc1
Relative Density.	1.21g/cm3

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (610.53 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4421 mL	12.2106 mL	24.4212 mL	122.1061 mL
5 mM	0.4884 mL	2.4421 mL	4.8842 mL	24.4212 mL
10 mM	0.2442 mL	1.2211 mL	2.4421 mL	12.2106 mL
20 mM	0.1221 mL	0.6105 mL	1.2211 mL	6.1053 mL
50 mM	0.0488 mL	0.2442 mL	0.4884 mL	2.4421 mL
100 mM	0.0244 mL	0.1221 mL	0.2442 mL	1.2211 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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