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Anti-OX40/TNFRSF4 Antibody-PE (9R426) is a PE-conjugated Rabbit antibody targeting OX40/TNFRSF4. Anti-OX40/TNFRSF4 Antibody-PE (9R426) can be used in FCM.
Description | Anti-OX40/TNFRSF4 Antibody-PE (9R426) is a PE-conjugated Rabbit antibody targeting OX40/TNFRSF4. Anti-OX40/TNFRSF4 Antibody-PE (9R426) can be used in FCM. |
Ig Type | Monoclonal Rabbit IgG |
Clone | 9R426 |
Reactivity | Mouse |
Verified Activity | Flow cytometric analysis of Mouse-OX40 expression on ConA-stimulated BABL/c splenocytesCells were stained with PE-conjugated anti-Mouse-OX40. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
Application | FCM |
Recommended Dose | 5 μl/Test, 0.1 mg/ml |
Antibody Type | Monoclonal |
Host Species | Rabbit |
Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse OX40 (rM OX40; TMPY-05020; NP_035789.1; Met1-Pro211) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
Purification | Protein A |
Appearance | Liquid |
Formulation | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
Research Background | OX40 (CD134) and its binding partner, OX40L (CD252), are members of the tumor necrosis factor receptor/tumor necrosis factor superfamily, is known to break an existing state of tolerance in malignancies, leading to a reactivation of antitumor immunity. The interaction between OX40 and OX40L plays an important role in antigen-specific T-cell expansion and survival. OX40 and OX40L also regulate cytokine production from T cells, antigen-presenting cells, natural killer cells, and natural killer T cells, and modulate cytokine receptor signaling. In line with these important modulatory functions, OX40-OX40L interactions have been found to play a central role in the development of multiple inflammatory and autoimmune diseases, making them attractive candidates for intervention in the clinic. Conversely, stimulating OX40 has shown it to be a candidate for therapeutic immunization strategies for cancer and infectious disease.Cancer ImmunotherapyCo-stimulatory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: WB AntibodiesImmune Checkpoint ProteinsImmune Checkpoint TargetsImmunotherapyTargeted Therapy |
Conjucates | PE |
Others Formats | Unconjugated/FITC |
Antibody Types Available | 3 |
Immunogen | Recombinant Mouse OX40 Protein (TMPY-05020) |
Antigen Species | Mouse |
Biology Area | Cancer Drug Targets |
Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. |
Transport | Shipping with blue ice. |
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