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Anti-Cytokeratin 20 Antibody (2X563)
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Catalog No. TMAB-04949 Copy Product Info
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Anti-Cytokeratin 20 Antibody (2X563) is a Mouse antibody targeting Cytokeratin 20. Anti-Cytokeratin 20 Antibody (2X563) can be used in IHC-P,IF,IHC-Fr.
Anti-Cytokeratin 20 Antibody
(2X563)
(2X563)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $220 | 7-10 days | 7-10 days | |
| 100 μL | $372 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-Cytokeratin 20 Antibody (2X563) is a Mouse antibody targeting Cytokeratin 20. Anti-Cytokeratin 20 Antibody (2X563) can be used in IHC-P,IF,IHC-Fr. |
| Ig Type | IgG2b,k |
| Clone | 2X563 |
| Reactivity | Human,Mouse,Rat |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IF: 1:100-500; IHC-Fr: 1:100-500 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Subcellular Localization | Cytoplasm. |
| Tissue Specificity | Expressed predominantly in the intestinal epithelium. Expressed in luminal cells of colonic mucosa. Also expressed in the Merkel cells of keratinized oral mucosa; specifically at the tips of some rete ridges of the gingival mucosa, in the basal layer of the palatal mucosa and in the taste buds of lingual mucosa. |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Proclin300. |
| Concentration | 1mg/ml |
| Research Background | Cytokeratin 20 is a type I keratin which is primarily expressed in gastric and intestinal epithelium, urothelium, and Merkel-cells. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Their genes are clustered in a region of chromosome 17q12-q21. Cytokeratin 20 is a major cellular protein of mature enterocytes and goblet cells and is specifically expressed in the gastric and intestinal mucosa. It is also expressed in adenocarcinomas of the colon, stomach, pancreas and the bile system and is present in mucinous ovarian tumors, transitional-cell and Merkel-cell carcinomas. Notably, the squamous cell carcinomas and adenocarcinomas of the breast, lung, and endometrium, non-mucinous tumors of the ovary, and small cell carcinomas lack cytokeratin 20. |
| Immunogen | KLH conjugated synthetic peptide: human CK20 |
| Antigen Species | Human |
| Gene Name | KRT20 |
| Gene ID | |
| Protein Name | Keratin, type I cytoskeletal 20 |
| Uniprot ID | |
| Function | Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity). |
| Molecular Weight | Theoretical: 48 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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