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Potassium 1H-indol-3-yl sulfate

🥰Excellent
Catalog No. T4938Cas No. 2642-37-7
Alias Potassium 3-indoxyl sulfate, Indoxyl sulfate potassium salt

Potassium 1H-indol-3-yl sulfate (Potassium 3-indoxyl sulfate) is an agonist for the human Aryl Hydrocarbon Receptor (AhR), a key regulator of immune-inflammatory conditions. A metabolite of tryptophan derived from dietary protein, it is produced by intestinal bacteria and metabolized in the liver. In chronic kidney disease patients with impaired renal function, it accumulates in serum as a uremic toxin, inducing oxidative stress and accelerating disease progression. At 250 μM, it activates NF-Κb, promoting TGF-β1 and Smad3 expression in rat proximal tubular cells, which is associated with profibrotic activity.

Potassium 1H-indol-3-yl sulfate

Potassium 1H-indol-3-yl sulfate

🥰Excellent
Purity: 99.71%
Catalog No. T4938Alias Potassium 3-indoxyl sulfate, Indoxyl sulfate potassium saltCas No. 2642-37-7
Potassium 1H-indol-3-yl sulfate (Potassium 3-indoxyl sulfate) is an agonist for the human Aryl Hydrocarbon Receptor (AhR), a key regulator of immune-inflammatory conditions. A metabolite of tryptophan derived from dietary protein, it is produced by intestinal bacteria and metabolized in the liver. In chronic kidney disease patients with impaired renal function, it accumulates in serum as a uremic toxin, inducing oxidative stress and accelerating disease progression. At 250 μM, it activates NF-Κb, promoting TGF-β1 and Smad3 expression in rat proximal tubular cells, which is associated with profibrotic activity.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$34In StockIn Stock
10 mg$54In StockIn Stock
25 mg$90In StockIn Stock
50 mg$139In StockIn Stock
100 mg$228In StockIn Stock
200 mg$343-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.71%
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COA LCMS HNMR HPLC

Product Introduction

Bioactivity
Description
Potassium 1H-indol-3-yl sulfate (Potassium 3-indoxyl sulfate) is an agonist for the human Aryl Hydrocarbon Receptor (AhR), a key regulator of immune-inflammatory conditions. A metabolite of tryptophan derived from dietary protein, it is produced by intestinal bacteria and metabolized in the liver. In chronic kidney disease patients with impaired renal function, it accumulates in serum as a uremic toxin, inducing oxidative stress and accelerating disease progression. At 250 μM, it activates NF-Κb, promoting TGF-β1 and Smad3 expression in rat proximal tubular cells, which is associated with profibrotic activity.
SynonymsPotassium 3-indoxyl sulfate, Indoxyl sulfate potassium salt
Chemical Properties
Molecular Weight251.3
FormulaC8H6KNO4S
Cas No.2642-37-7
Smiles[K+].[O-]S(=O)(=O)Oc1c[nH]c2ccccc12
Relative Density.no data available
ColorYellow
AppearanceSolid
Storage & Solubility Information
Storagestore at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 3 months | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 100 mg/mL (397.93 mM), Sonication is recommended.
H2O: 50 mg/mL (198.97 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (15.92 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM3.9793 mL19.8965 mL39.7931 mL198.9654 mL
5 mM0.7959 mL3.9793 mL7.9586 mL39.7931 mL
10 mM0.3979 mL1.9897 mL3.9793 mL19.8965 mL
20 mM0.1990 mL0.9948 mL1.9897 mL9.9483 mL
50 mM0.0796 mL0.3979 mL0.7959 mL3.9793 mL
100 mM0.0398 mL0.1990 mL0.3979 mL1.9897 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

Potassium 3-indoxyl SulfatePotassium 1H-indol-3-yl SulfatePotassium 1Hindol3yl sulfatePotassium 1H indol 3 yl sulfateInhibitorinhibitIndoxyl sulfate potassiumEndogenousMetaboliteEndogenous MetaboliteAhR
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