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α-Thujone

🥰Excellent
Catalog No. T8193Cas No. 546-80-5
Alias Thujone, ALPHA-(-)-THUJONE

α-Thujone is an inhibitor of ACh with an IC50 value of 24.7μM.

α-Thujone

α-Thujone

🥰Excellent
Purity: 98.41%
Catalog No. T8193Alias Thujone, ALPHA-(-)-THUJONECas No. 546-80-5
α-Thujone is an inhibitor of ACh with an IC50 value of 24.7μM.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$40-In Stock
10 mg$64-In Stock
25 mg$133-In Stock
50 mg$215-In Stock
100 mg$347In StockIn Stock
1 mL x 10 mM (in DMSO)$44-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.41%
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COA HNMR

Product Introduction

Bioactivity
Description
α-Thujone is an inhibitor of ACh with an IC50 value of 24.7μM.
Targets&IC50
α7 nAChR:24.7μM
In vitro
In in-vivo one-trial passive avoidance paradigm show that thujone (1.25mg/kg, i.p.) significantly impaired nicotine-induced enhancement of learning and memory in Wistar rats[1].
SynonymsThujone, ALPHA-(-)-THUJONE
Chemical Properties
Molecular Weight152.23
FormulaC10H16O
Cas No.546-80-5
Smiles[H][C@]12C[C@]1(CC(=O)[C@@H]2C)C(C)C
Relative Density.0.914 g/mL at 20°C(lit.)
ColorTransparent
AppearanceOil
Storage & Solubility Information
Storagestore at low temperature,keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 4.4 mg/mL (28.9 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (6.57 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM6.5690 mL32.8450 mL65.6901 mL328.4504 mL
5 mM1.3138 mL6.5690 mL13.1380 mL65.6901 mL
10 mM0.6569 mL3.2845 mL6.5690 mL32.8450 mL
20 mM0.3285 mL1.6423 mL3.2845 mL16.4225 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

γ-Aminobutyric acid Receptorα-ThujoneαThujoneα ThujonestressROSReactiveOxygenSpeciesReactive Oxygen Speciespro-apoptoticParasiteoxidativeMonoterpeneinsecticidalInhibitorinhibitGamma-aminobutyric acid ReceptorGABAReceptorGABAAGABA ReceptorBBBAutophagya-ThujoneApoptosisanti-tumorantinociceptiveanti-invasiveanthelminticALPHA-THUJONEAChR
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