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ESI-08

Name: ESI-08
Brand: TargetMol
SKU: T11234
Price: 51 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11234Cas No. 301177-43-5

ESI-08 is an effective antagonist of EPAC2 with an IC50 of 8.4 μM. ESI-08 selectively blocks cAMP-induced EPAC activation but not cAMP-mediated PKA activation.

ESI-08

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Purity: 97.17%

Catalog No. T11234Cas No. 301177-43-5

ESI-08 is an effective antagonist of EPAC2 with an IC50 of 8.4 μM. ESI-08 selectively blocks cAMP-induced EPAC activation but not cAMP-mediated PKA activation.

Pack Size	Price	Availability
1 mg	$51	In Stock
5 mg	$122	In Stock
10 mg	$198	In Stock
25 mg	$455	In Stock
1 mL x 10 mM (in DMSO)	$135	In Stock

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Purity:97.17%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	ESI-08 is an effective antagonist of EPAC2 with an IC50 of 8.4 μM. ESI-08 selectively blocks cAMP-induced EPAC activation but not cAMP-mediated PKA activation.
Targets&IC50	EPAC2:8.4 μM
In vitro	ESI-08 (25 μM) does not alter cAMP-induced type I and II PKA holoenzymes activation while H89, a selective PKA inhibitor, blocked the type I or II PKA activities completely[1].

Chemical Properties

Molecular Weight	353.48
Formula	C₂₀H₂₃N₃OS
Cas No.	301177-43-5
Smiles	Cc1ccc(C)c(CSc2nc(C3CCCCC3)c(C#N)c(=O)[nH]2)c1
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (141.45 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8290 mL	14.1451 mL	28.2901 mL	141.4507 mL
5 mM	0.5658 mL	2.8290 mL	5.6580 mL	28.2901 mL
10 mM	0.2829 mL	1.4145 mL	2.8290 mL	14.1451 mL
20 mM	0.1415 mL	0.7073 mL	1.4145 mL	7.0725 mL
50 mM	0.0566 mL	0.2829 mL	0.5658 mL	2.8290 mL
100 mM	0.0283 mL	0.1415 mL	0.2829 mL	1.4145 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc