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Anti-CD156B Monoclonal Antibody (3Z451)
(Synonyms: TACE, NISBD1, NISBD, CSVP, ADAM18, ADAM17) Copy Product Info
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Synonyms: TACE, NISBD1, NISBD, CSVP, ADAM18, ADAM17
Catalog No. TMAT-0280 Copy Product Info
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Anti-CD156B Monoclonal Antibody (3Z451) is a Mouse antibody targeting CD156B. Anti-CD156B Monoclonal Antibody (3Z451) can be used in WB,IF,FCM.
Anti-CD156B Monoclonal Antibody
(3Z451)
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Stability & Storage
| Description | Anti-CD156B Monoclonal Antibody (3Z451) is a Mouse antibody targeting CD156B. Anti-CD156B Monoclonal Antibody (3Z451) can be used in WB,IF,FCM. |
| Synonyms | TACE, NISBD1, NISBD, CSVP, ADAM18, ADAM17 |
| Ig Type | IgG1 |
| Clone | 3Z451 |
| Reactivity | Human, Mouse |
| Application | |
| Recommended Dose | WB: 1/500-1/2000; IF: 1/200-1/1000; FCM: 1/200-1/400 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | PBS with 0.05% sodium azide |
| Concentration | 1 mg/ml |
| Research Background | This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha, in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous other substrates, including cell adhesion proteins, cytokine and growth factor receptors and epidermal growth factor (EGF) receptor ligands, and plays a prominent role in the activation of the Notch signaling pathway. Elevated expression of this gene has been observed in specific cell types derived from psoriasis, rheumatoid arthritis, multiple sclerosis and Crohn's disease patients, suggesting that the encoded protein may play a role in autoimmune disease. Additionally, this protease may play a role in viral infection through its cleavage of ACE2, the cellular receptor for SARS-CoV and SARS-CoV-2. |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of human CD156B (AA: 497-671) expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | ADAM17 |
| Gene ID | |
| Protein Name | Disintegrin and metalloproteinase domain-containing protein 17 |
| Uniprot ID |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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