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Anti-EPCR Antibody (4A726)
😃Good
Catalog No. TMAY-02559
Alias protein C receptor, endothelial
Anti-EPCR Antibody (4A726) is a Rabbit antibody targeting EPCR. Anti-EPCR Antibody (4A726) can be used in IHC-P.
Anti-EPCR Antibody (4A726)
Anti-EPCR Antibody (4A726)
😃Good
Catalog No. TMAY-02559Alias protein C receptor, endothelial
Anti-EPCR Antibody (4A726) is a Rabbit antibody targeting EPCR. Anti-EPCR Antibody (4A726) can be used in IHC-P.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 20 μL | $92 | 7-10 days | 7-10 days | |
| 100 μL | $268 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-EPCR Antibody (4A726) is a Rabbit antibody targeting EPCR. Anti-EPCR Antibody (4A726) can be used in IHC-P. |
| Synonyms | protein C receptor, endothelial |
| Ig Type | Rabbit IgG |
| Clone | 4A726 |
| Reactivity | Human |
| Specificity | Human EPCR No cross-reactivity in ELISA with Mouse PROCR |
| Verified Activity | 1. Immunochemical staining of human PROCR in human liver with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). 2. Immunochemical staining of human PROCR in human kidney with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). |
| Application | |
| Recommended Dose | IHC-P: 1:100-1:500 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human Epcr / PROCR (rh Epcr / PROCR; TMPY-02715; Q9UNN8; Met1-Thr209). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Endothelial protein C receptor (EPCR), also known as activated protein C receptor (APC receptor) or PROCR, is a receptor for Protein C. Protein C plays an important role in many metabolism processes in humans and other animals after activated by binding to Endothelial protein C receptor (EPCR). Because of the EPCR is found primarily on endothelial cells (cells on the inside of blood vessels), activated protein C is found mainly near endothelial cells. Protein C is pleiotropic, with two main functions: anticoagulation and cytoprotection. Which function will be performed depending on whether or not protein C remains bind to EPCR after activated. The anticoagulation occurs when it does not. In this case, protein C functions as an anticoagulant by irreversibly proteolytically inactivating Factor Va and Factor VIIIa, turning them into Factor Vi and Factor VIIIi respectively. When still bound to EPCR, activated protein C performs its cytoprotective effects, acting on the effector substrate PAR-1, protease-activated receptor-1. To a degree, APC's anticoagulant properties are independent of its cytoprotective ones, in that expression of one pathway is not affected by the existence of the other. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human Epcr / PROCR protein (TMPY-02715) |
| Antigen Species | Human |
| Biology Area | Serine Proteases and Regulators |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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