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Terevalefim

🥰Excellent
Catalog No. T37596Cas No. 1070881-42-3

Terevalefim (ANG-3777) is an hepatocyte growth factor (HGF) mimetic. Terevalefim selectively activates the c-Met receptor.

Terevalefim

Terevalefim

🥰Excellent
Purity: 99.8%
Catalog No. T37596Cas No. 1070881-42-3
Terevalefim (ANG-3777) is an hepatocyte growth factor (HGF) mimetic. Terevalefim selectively activates the c-Met receptor.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$51In StockIn Stock
5 mg$122In StockIn Stock
10 mg$222In StockIn Stock
25 mg$388In StockIn Stock
50 mg$566In StockIn Stock
100 mg$790In StockIn Stock
500 mg$1,620-In Stock
1 mL x 10 mM (in DMSO)$122In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.8%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
Terevalefim (ANG-3777) is an hepatocyte growth factor (HGF) mimetic. Terevalefim selectively activates the c-Met receptor.
In vitro
Terevalefim (ANG-3777) (0-10 μM) significantly inhibited cancer cell proliferation in HUVECs[2].
In vivo
Terevalefim (ANG-3777) reduces apoptosis, enhances proliferation, and supports organ repair and function in animal models[1]. Additionally, Terevalefim (ANG-3777, 40 mg/kg, IP) induces phosphorylation of the c-Met receptor in rats[2].
Chemical Properties
Molecular Weight176.24
FormulaC9H8N2S
Cas No.1070881-42-3
SmilesC(=C/c1cccs1)\c1cc[nH]n1
Relative Density.1.318 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 100 mg/mL (567.41 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (22.7 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM5.6741 mL28.3704 mL56.7408 mL283.7040 mL
5 mM1.1348 mL5.6741 mL11.3482 mL56.7408 mL
10 mM0.5674 mL2.8370 mL5.6741 mL28.3704 mL
20 mM0.2837 mL1.4185 mL2.8370 mL14.1852 mL
50 mM0.1135 mL0.5674 mL1.1348 mL5.6741 mL
100 mM0.0567 mL0.2837 mL0.5674 mL2.8370 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

transplantationTerevalefimkidneyinjuryInhibitorinhibitHGFRHGFc-Met/HGFRcMet/HGFRc-MetcMetANG-3777ANG3777ANG 3777AKIacute
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