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Terevalefim

Catalog No. T37596 CAS 1070881-42-3

Terevalefim (ANG-3777) is an hepatocyte growth factor (HGF) mimetic. Terevalefim selectively activates the c-Met receptor.

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Terevalefim, CAS 1070881-42-3

Pack Size	Availability	Price/USD
2 mg	In stock	$ 97.00
5 mg	In stock	$ 137.00
10 mg	In stock	$ 248.00
25 mg	In stock	$ 491.00
50 mg	In stock	$ 815.00
100 mg	In stock	$ 1,487.00
200 mg	In stock	$ 2,227.00
500 mg	In stock	$ 3,347.00
1 mL * 10 mM (in DMSO)	In stock	$ 163.00

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Purity: 98%

Biological Description

Chemical Properties

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Description	Terevalefim (ANG-3777) is an hepatocyte growth factor (HGF) mimetic. Terevalefim selectively activates the c-Met receptor.
In vitro	Terevalefim (ANG-3777) (0-10 μM) significantly inhibited cancer cells proliferation in HUVECs[2].
In vivo	Terevalefim (ANG-3777) decreases apoptosis, increases proliferation, and promotes organ repair and function in animal models[1].Terevalefim (ANG-3777, 40 mg/kg, IP) phosphorylates the c-Met receptor in rats[2].

Molecular Weight	176.24
Formula	C9H8N2S
CAS No.	1070881-42-3

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 100 mg/mL (567.41 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Jonathan S Bromberg, et al. Renal Function Improvement Following ANG-3777 Treatment in Patients at High Risk for Delayed Graft Function After Kidney Transplantation. Transplantation. 2021 Feb 1;105(2):443-450. 2. Latha Paka, et al. The Effect of ANG-3777 on Hepatocyte Growth Factor Receptor, c-MET Signaling. American Transplant Society.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Liver Cancer Compound Library Anti-Cancer Clinical Compound Library Bioactive Compounds Library Max Anti-Cancer Drug Library Anti-Cancer Compound Library Clinical Compound Library Anti-Colorectal Cancer Compound Library Bioactive Compound Library Drug Repurposing Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Terevalefim 1070881-42-3 Tyrosine Kinase/Adaptors c-Met/HGFR ANG-3777 injury acute inhibit ANG 3777 AKI kidney ANG3777 transplantation HGF Inhibitor inhibitor

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