Shopping Cart

Your shopping cart is currently empty

Octocrylene

Name: Octocrylene
Brand: TargetMol
SKU: T0402
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T0402Cas No. 6197-30-4

Alias Octocrilene

Octocrylene (Octocrilene) is used as an ingredient in sunscreens and cosmetics. This organic compound can penetrate into the skin where it acts as a photosensitizer. This results in an increased production of free radicals under illumination.

Octocrylene

Copy Product Info

😃Good

Purity: 99.21%

Catalog No. T0402Alias OctocrileneCas No. 6197-30-4

Pack Size	Price	USA Warehouse	Global Warehouse
1 g	$34	In Stock	-
5 g	$48	Inquiry	Inquiry
10 g	$78	-	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	-

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.21%

Appearance:Liquid

Color:Transparent

Resource Download

COA LCMS HNMR

Product Introduction

Octocrylene AI Summary

Octocrylene exhibits a broad spectrum of bioactivities across various assays, including antiviral activity against SARS-CoV-2 (USA-WA1/2020 strain), inhibition of Lamin A splicing, Cruzain (with/without detergent), and Aldehyde Dehydrogenase 1. It modulates lipid storage in Drosophila cells, inhibits the ERK signaling pathway, anthrax lethal toxin internalization, ROR gamma transcriptional activity, GCN5L2, T. brucei phosphofructokinase, histone lysine methyltransferase G9a, and plastid function in malarial parasites. Additionally, it inhibits polymerases Iota and Kappa, mammalian selenoprotein thioredoxin reductase 1, USP1/UAF1, the hERG channel, tyrosyl-DNA phosphodiesterase 1, and hepatitis C virus. It also acts as an agonist and antagonist of various nuclear receptors, an activator of antioxidant response element (ARE) signaling pathway, and a disruptor of mitochondrial membrane potential. The compound further exhibits cytotoxicity against dead cells, induction of synthetic lethality in tumor cells, and barrier activity against Ebola virus entry, with antiviral potential against Foot and Mouth Disease Virus. Moreover, it promotes cell viability through ATP metabolic activity, induces DNA re-replication in SW480 colon adenocarcinoma cells, and impacts VEGF-stimulated cell co-culture nuclear and tube areas. With a hit score of 0.1632 in the HRCE cell imaging assay, Octocrylene indicates moderate antiviral activity against SARS-CoV-2, revealing significant potential in influencing diverse cellular processes and signaling pathways..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Octocrylene (Octocrilene) is used as an ingredient in sunscreens and cosmetics. This organic compound can penetrate into the skin where it acts as a photosensitizer. This results in an increased production of free radicals under illumination.
Synonyms	Octocrilene

Chemical Properties

Molecular Weight	361.48
Formula	C₂₄H₂₇NO₂
Cas No.	6197-30-4
Smiles	C(=C(C(OCC(CCCC)CC)=O)C#N)(C1=CC=CC=C1)C2=CC=CC=C2
Relative Density.	1.051 g/cm3 at 25℃ (lit.)

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (124.49 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.53 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7664 mL	13.8320 mL	27.6640 mL	138.3202 mL
5 mM	0.5533 mL	2.7664 mL	5.5328 mL	27.6640 mL
10 mM	0.2766 mL	1.3832 mL	2.7664 mL	13.8320 mL
20 mM	0.1383 mL	0.6916 mL	1.3832 mL	6.9160 mL
50 mM	0.0553 mL	0.2766 mL	0.5533 mL	2.7664 mL
100 mM	0.0277 mL	0.1383 mL	0.2766 mL	1.3832 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc