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Curcumol

Name: Curcumol
Brand: TargetMol
SKU: T2853
Price: 43 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2853Cas No. 4871-97-0

Alias (-)-Curcumol

Curcumol ((-)-Curcumol), a pure monomer derived from Rhizoma Curcumaeis, exhibits antitumor activities.

Curcumol

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Purity: 99.87%

Catalog No. T2853Alias (-)-CurcumolCas No. 4871-97-0

Curcumol ((-)-Curcumol), a pure monomer derived from Rhizoma Curcumaeis, exhibits antitumor activities.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$43	In Stock	In Stock
10 mg	$61	In Stock	In Stock
25 mg	$97	In Stock	In Stock
50 mg	$148	In Stock	In Stock
100 mg	$218	In Stock	In Stock
200 mg	$327	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$46	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.87%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Curcumol ((-)-Curcumol), a pure monomer derived from Rhizoma Curcumaeis, exhibits antitumor activities.
In vivo	In fibroblast-like synoviocytes, Curcumol can inhibit cell proliferation and DNA synthesis, contributing to the improvement of rheumatoid arthritis. In human lung adenocarcinoma cells, Curcumol induces cell death through the induction of G(2)/M phase arrest, nuclear fragmentation, externalization of phosphatidylserine, and rapid translocation of Bax from the cytoplasm to the mitochondria.
Synonyms	(-)-Curcumol

Chemical Properties

Molecular Weight	236.35
Formula	C₁₅H₂₄O₂
Cas No.	4871-97-0
Smiles	[H][C@@]12CC[C@H](C)[C@@]11C[C@@H](C(C)C)[C@@](O)(CC2=C)O1
Relative Density.	1.06 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 44 mg/mL (186.16 mM), Sonication is recommended.

DMSO: 44 mg/mL (186.16 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+90% Corn Oil: 2 mg/mL (8.46 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.2310 mL	21.1551 mL	42.3101 mL	211.5507 mL
5 mM	0.8462 mL	4.2310 mL	8.4620 mL	42.3101 mL
10 mM	0.4231 mL	2.1155 mL	4.2310 mL	21.1551 mL
20 mM	0.2116 mL	1.0578 mL	2.1155 mL	10.5775 mL
50 mM	0.0846 mL	0.4231 mL	0.8462 mL	4.2310 mL
100 mM	0.0423 mL	0.2116 mL	0.4231 mL	2.1155 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc