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USP7-IN-4

Name: USP7-IN-4
Brand: TargetMol
SKU: T69820
Price: 333 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T69820Cas No. 2196243-57-7

Alias USP7-IN-2, USP7 inhibitor ALM4, AD-04

USP7-IN-4(USP7 inhibitor ALM4) is a non-competitive, potent and selective inhibitor of USP7 (ubiquitin-specific protease 7) with an IC50 = 6 nM, up-regulates p53 and p21, down-regulates MDM2, increases the level of ubiquitination of MDM2, and exhibits anti-proliferative activity in a variety of cancer cell lines, with an EC50 = 2.0 nM in RS4;11 (acute lymphoblastic leukemia cell line) .

USP7-IN-4

🥰Excellent

Purity: 100%

Catalog No. T69820Alias USP7-IN-2, USP7 inhibitor ALM4, AD-04Cas No. 2196243-57-7

Pack Size	Price	Availability
1 mg	$333	In Stock
5 mg	$790	In Stock
10 mg	$1,120	In Stock
25 mg	$1,670	In Stock
50 mg	$2,180	In Stock
100 mg	$2,800	In Stock

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Purity:100%

ee:100%

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COA CSFC HNMR HPLC LCMS ORP

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	USP7-IN-4(USP7 inhibitor ALM4) is a non-competitive, potent and selective inhibitor of USP7 (ubiquitin-specific protease 7) with an IC50 = 6 nM, up-regulates p53 and p21, down-regulates MDM2, increases the level of ubiquitination of MDM2, and exhibits anti-proliferative activity in a variety of cancer cell lines, with an EC50 = 2.0 nM in RS4;11 (acute lymphoblastic leukemia cell line) .
Alias	USP7-IN-2, USP7 inhibitor ALM4, AD-04

Chemical Properties

Molecular Weight	514.62
Formula	C₂₉H₃₄N₆O₃
Cas No.	2196243-57-7
Smiles	CN1C(=C2C(C(=O)N(CC3(O)CCN(C(C[C@@H](C)C4=CC=CC=C4)=O)CC3)C=N2)=N1)C5=CC=C(CN)C=C5

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc