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Nanchangmycin

Name: Nanchangmycin
Brand: TargetMol
SKU: T6601
Price: 58 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6601Cas No. 65101-87-3

Alias Nanchangmycin A

Nanchangmycin (Nanchangmycin A), a polyether antibiotic, is similar to the structure of dianemycin. It is very potent against the broad spectrum of harmful nematodes and insects but not for mammals and plants.

Nanchangmycin

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Purity: 99.13%

Catalog No. T6601Alias Nanchangmycin ACas No. 65101-87-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$58	-	In Stock
5 mg	$139	-	In Stock
10 mg	$222	-	In Stock
25 mg	$446	-	In Stock
1 mL x 10 mM (in DMSO)	$217	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.13%

Appearance:Solid

Color:White to Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Nanchangmycin (Nanchangmycin A), a polyether antibiotic, is similar to the structure of dianemycin. It is very potent against the broad spectrum of harmful nematodes and insects but not for mammals and plants.
In vitro	Nanchangmycin resists gram-positive bacteria.
In vivo	Nanchangmycin, a growth promoter in poultry, cures coccidiosis in chickens. Nanchangmycin, a bacterially-derived natural product, blocks ZIKV and DENV infection potently in diverse cell types.
Kinase Assay	Histone deacetylase activity:For PCI-34051 characterization, measurements are performed in a reaction volume of 100 μL using 96-well assay plates in a fluorescence plate reader. For each isozyme. The HDAC protein in reaction buffer (50 mM HEPES, 100 mM KCl, 0.001% Tween-20, 5% dimethyl sulfoxide, pH7.4, supplemented with bovine serum albumin at concentrations of 0-0.05%) is mixed with PCI-34051 at various concentrations and allowed to incubate for 15 min. Trypsin is added to a final concentration of 50 nM, and acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methyl coumarin is added to a final concentration of 25-100 μM to initiate the reaction. After a 30 min lag time, the fluorescence is measured over a 30 min time frame using an excitation wavelength of 335 nm and a detection wavelength of 460 nm. The increase in fluorescence with time is used as the measure of the reaction rate.
Cell Research	5×10E3 U2OS cells were plated in 25ul media per well in 384-well plates and cultured for 24 hours. Add 50 nl of Nanchangmycin, which is 0.7uM dissolved in 0.2% DMSO, to each well incubating for 1 hour.
Synonyms	Nanchangmycin A

Chemical Properties

Molecular Weight	889.1
Formula	C₄₇H₇₇NaO₁₄
Cas No.	65101-87-3
Smiles	C[C@H]1[C@@]2(O[C@]([C@@]3([H])O[C@](O)([C@@H](C[C@@H]3C)C)CO)([H])C[C@@H]2C)O[C@]([C@]4(O[C@]5(O[C@]([C@@H]([C@H](C5)O)C)([H])[C@@H](C)/C=C(C)/C([C@H](C)C[C@H](C)C([O-])=O)=O)CC4)C)([H])C[C@@H]1O[C@H]6O[C@@H]([C@H](CC6)OC)C.[Na+]
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 88.9 mg/mL (99.99 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (3.71 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1247 mL	5.6237 mL	11.2473 mL	56.2366 mL
5 mM	0.2249 mL	1.1247 mL	2.2495 mL	11.2473 mL
10 mM	0.1125 mL	0.5624 mL	1.1247 mL	5.6237 mL
20 mM	0.0562 mL	0.2812 mL	0.5624 mL	2.8118 mL
50 mM	0.0225 mL	0.1125 mL	0.2249 mL	1.1247 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc