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Anti-human CD34 Antibody (3W683)
😃Good
Catalog No. TMAB-07404
Anti-human CD34 Antibody (3W683) is a Mouse antibody targeting human CD34. Anti-human CD34 Antibody (3W683) can be used in FCM.
Anti-human CD34 Antibody (3W683)
Anti-human CD34 Antibody (3W683)
😃Good
Catalog No. TMAB-07404
Anti-human CD34 Antibody (3W683) is a Mouse antibody targeting human CD34. Anti-human CD34 Antibody (3W683) can be used in FCM.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 100 μg | $354 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-human CD34 Antibody (3W683) is a Mouse antibody targeting human CD34. Anti-human CD34 Antibody (3W683) can be used in FCM. |
| Ig Type | Mouse IgG1 |
| Clone | 3W683 |
| Reactivity | Human |
| Application | |
| Recommended Dose | FCM: 0.5μg/Test |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Subcellular Localization | Membrane; Single-pass type I membrane protein. |
| Tissue Specificity | Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues. |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Protein G purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4). |
| Concentration | 1mg/ml |
| Research Background | The highly glycosylated 75-120 kD antigen CD34 is possibly an adhesion molecule with a putative role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. It could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. CD34 is thought to have a role in presenting carbohydrate ligands to selectins. The intracellular chain of the CD34 antigen is a site of phosphorylation by activated protein kinase C, suggesting a putative role in signal transduction. Two isoforms of CD34 have been reported to be generated by alternative splicing. CD34 is highly expressed on hematopoietic progenitors, as well as on endothelial cells, brain, and testis. Staining for CD34 has been used to measure angiogenesis, which reportedly predicts tumor recurrence. |
| Immunogen | KLH conjugated synthetic peptide: human CD34 |
| Antigen Species | Human |
| Gene Name | CD34 |
| Gene ID | |
| Protein Name | Hematopoietic progenitor cell antigen CD34 |
| Uniprot ID | |
| Function | Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins. |
| Molecular Weight | Theoretical: 39 kDa. Actual: 105-120 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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