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Anti-MERTK/Mer Antibody (7Y17)
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Catalog No. TMAY-00582
Alias Tyro12, RP38, MGC133349, MERTK, MER, c-mer, c-Eyk
Anti-MERTK/Mer Antibody (7Y17) is a Mouse antibody targeting MERTK/Mer. Anti-MERTK/Mer Antibody (7Y17) can be used in ELISA.
Anti-MERTK/Mer Antibody (7Y17)
Anti-MERTK/Mer Antibody (7Y17)
😃Good
Catalog No. TMAY-00582Alias Tyro12, RP38, MGC133349, MERTK, MER, c-mer, c-Eyk
Anti-MERTK/Mer Antibody (7Y17) is a Mouse antibody targeting MERTK/Mer. Anti-MERTK/Mer Antibody (7Y17) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $198 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-MERTK/Mer Antibody (7Y17) is a Mouse antibody targeting MERTK/Mer. Anti-MERTK/Mer Antibody (7Y17) can be used in ELISA. |
| Alias | Tyro12, RP38, MGC133349, MERTK, MER, c-mer, c-Eyk |
| Ig Type | Monoclonal Mouse IgG2b |
| Clone | 7Y17 |
| Reactivity | Human |
| Application | ELISA |
| Recommended Dose | ELISA: 1:1000-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human MERTK/Mer (rh MERTK/Mer; TMPY-04330; NP_006334.2; Met1-Ala499). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Proto-oncogene tyrosine-protein kinase MER (MERTK) is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. MERTK is localized in the membrane and is no expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines. This protein is highly expressed in the testis, ovary, prostate, lung, and kidney, with lower expression in the spleen, small intestine, colon, and liver. MERTK regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization, and engulfment. MERTK plays also an important role in the inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces the production of suppressors of cytokine signaling SOCS1 and SOCS3. Defects in MERTK are the cause of retinitis pigmentosa type 38. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human MERTK/Mer Protein (TMPY-04330) |
| Antigen Species | Human |
| Biology Area | Receptor Tyrosine Kinases (RTKs) |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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