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Pyrrolnitrin

Catalog No. T38413 CAS 1018-71-9

Pyrrolnitrin, an antibiotic derived from Pseudomonas pyrrocinia, exhibits a broad spectrum of antibiotic activity, effectively targeting fungi, yeast, and gram-positive bacteria.

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Pyrrolnitrin, CAS 1018-71-9

Pack Size	Availability	Price/USD
500 μg	35 days	$ 397.00
1 mg	35 days	$ 778.00
5 mg	35 days	$ 2,650.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Pyrrolnitrin, an antibiotic derived from Pseudomonas pyrrocinia, exhibits a broad spectrum of antibiotic activity, effectively targeting fungi, yeast, and gram-positive bacteria.

In vitro

Pyrrolnitrin, at concentrations ranging from 0 to 100 μg/ml, demonstrates potent antibiotic properties against a diverse array of bacteria and fungi, exhibiting varying Minimum Inhibitory Concentration (MIC) values. Specifically, it is effective against Staphylococcus aureus, Mycobacterium, Bacillus subtillis, Candida albicans, Aspergillus niger, and Trichophyton rubrum, with respective MIC values of 50 μg/ml, 100 μg/ml, 0.78 μg/ml, 10 μg/ml, 12.5 μg/ml, and 1 μg/ml[1]. Additionally, when assessed in a microtitre plate assay, Pyrrolnitrin shows an antimicrobial effect against Arthrobacter oxydans ATCC 14358, Bacillus coagulans ATCC 7050, Bacillus licheniformis ATCC 14580, Bacillus subtilis ATCC 6051, and Bacillus thuringiensis ATCC 10792, all with an MIC of 6.25 μg/ml[2].

Molecular Weight	257.07
Formula	C10H6Cl2N2O2
CAS No.	1018-71-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. K H van Pée, et al. Biosynthesis of Pyrrolnitrin and Other Phenylpyrrole Derivatives by Bacteria. Nat Prod Rep. 2000 Apr;17(2):157-64. 2. N el-Banna, et al. Pyrrolnitrin From Burkholderia Cepacia: Antibiotic Activity Against Fungi and Novel Activities Against Streptomycetes.J Appl Microbiol. 1998 Jul;85(1):69-78. 3. R S Gordee, et al.Systemic Antifungal Activity of Pyrrolnitrin.Appl Microbiol. 1969 May;17(5):690-4.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Pyrrolnitrin 1018-71-9 inhibitor inhibit

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