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Anti-Cadherin 17/CDH17 Antibody (2F618)
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Catalog No. TMAY-01847
Alias cadherin 17, LI cadherin (liver-intestine)
Anti-Cadherin 17/CDH17 Antibody (2F618) is a Mouse antibody targeting Cadherin 17/CDH17. Anti-Cadherin 17/CDH17 Antibody (2F618) can be used in ELISA.
Anti-Cadherin 17/CDH17 Antibody (2F618)
Anti-Cadherin 17/CDH17 Antibody (2F618)
😃Good
Catalog No. TMAY-01847Alias cadherin 17, LI cadherin (liver-intestine)
Anti-Cadherin 17/CDH17 Antibody (2F618) is a Mouse antibody targeting Cadherin 17/CDH17. Anti-Cadherin 17/CDH17 Antibody (2F618) can be used in ELISA.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 20 μL | $70 | 7-10 days | 7-10 days | |
| 100 μL | $199 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-Cadherin 17/CDH17 Antibody (2F618) is a Mouse antibody targeting Cadherin 17/CDH17. Anti-Cadherin 17/CDH17 Antibody (2F618) can be used in ELISA. |
| Synonyms | cadherin 17, LI cadherin (liver-intestine) |
| Ig Type | Mouse IgG2a |
| Clone | 2F618 |
| Reactivity | Human |
| Specificity | Human Cadherin-17 No cross-reactivity in ELISA with Human Cadherin-5 Human Cadherin-8 Human E-Cadherin Human cell lysate (293 cell line) |
| Application | |
| Recommended Dose | ELISA: 1:1000-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CDH17 / Cadherin-17 (rh CDH17 / Cadherin-17; Catalog #11360-H08H; Met 1-Met 787; Q12864-1). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Cadherin-17 or LI-cadherin is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Cadherin-17/LI-cadherin is a cadherin-like protein consisting of an extracellular region, 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing of the encoding gene results in multiple transcript variants. Cadherin-17/LI-cadherin preferentially interact with themselves in a homophilic manner in connecting cells. Cadherin-17 may thus contribute to the sorting of heterogeneous cell types and have a role in the morphological organization of liver and intestine. It's also involved in intestinal peptide transport. Experiments have reported the association between Cadherin-17/LI-cadherin and gastric cancer. Cadherin-17/LI-cadherin expression was detected in 63/94 of gastric adenocarcinomas in addition to intestinal metaplasia. The expression of Cadherin-17 tended to be associated with intestinal type carcinoma, and carcinomas with Cadherin-17 expression was significantly more frequent in advanced stage cases than in early stage. Cadherin-17 is also a useful immunohistochemical marker for diagnosis of adenocarcinomas of the digestive system. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human CDH17 / Cadherin-17 Protein (TMPY-01912) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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