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Neobavaisoflavone
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Catalog No. T6S0139Cas No. 41060-15-5
1. Neobavaisoflavone is isolated as a DNA polymerase inhibitor. 2. Neobavaisoflavone might be a potential anabolic agent to treat bone loss-associated diseases. 3. Neobavaisoflavone has anti-inflammatory activity, can significantly inhibit the production of reactive oxygen species (ROS), reactive nitrogen species (RNS) and cytokines: IL-1β, IL-6, IL-12p4, IL-12p7, TNF-α in LPS+IFN-γ- or PMA- stimulated RAW264.7 macrophages.
Neobavaisoflavone
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Purity: 99.92%
Catalog No. T6S0139Cas No. 41060-15-5
1. Neobavaisoflavone is isolated as a DNA polymerase inhibitor. 2. Neobavaisoflavone might be a potential anabolic agent to treat bone loss-associated diseases. 3. Neobavaisoflavone has anti-inflammatory activity, can significantly inhibit the production of reactive oxygen species (ROS), reactive nitrogen species (RNS) and cytokines: IL-1β, IL-6, IL-12p4, IL-12p7, TNF-α in LPS+IFN-γ- or PMA- stimulated RAW264.7 macrophages.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $40 | In Stock | In Stock | |
| 10 mg | $64 | In Stock | In Stock | |
| 25 mg | $106 | In Stock | In Stock | |
| 50 mg | $155 | In Stock | In Stock | |
| 100 mg | $228 | - | In Stock | |
| 500 mg | $568 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $44 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.92%
Appearance:Solid
Color:White to Yellow
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Product Introduction
Neobavaisoflavone AI Summary
Neobavaisoflavone exhibits diverse biological activities, including significant antimutagenic effects in Salmonella Typhimurium T98 with inhibition percentages ranging from 15.0% to 98.0% against various mutagens. The compound also shows toxicity at concentrations of 300-600 µg/plate in the same bacteria. Additionally, Neobavaisoflavone demonstrates antiplatelet activity in rabbit platelets, inhibiting collagen, arachidonic acid, and platelet-activating factor-induced aggregation with IC50 values of 62400.0 nM, 7800.0 nM, and 2500.0 nM, respectively.
The compound has potent antibacterial activity against Staphylococcus aureus with a MIC of 3.2 µg/mL and antifungal activity against Aspergillus fumigatus and Cryptococcus neoformans with MIC values of 50.0 µg/mL. It also shows an inhibition of melanin synthesis in normal human epidermal melanocytes (NHEM), achieving an IC50 of 9400.0 nM.
In terms of enzyme inhibition, Neobavaisoflavone inhibits Streptococcus mutans recombinant sortase A delta-40 mutant with an IC50 of 284100.0 nM and exhibits cytotoxicity against human K562 and A549 cells with IC50 values greater than 10000.0 nM. The compound induces DNA damage in human SU8686 cells by increasing gammaH2AX phosphorylation in the presence of cisplatin and doxorubicin.
Additionally, Neobavaisoflavone exhibits antiviral activities, inhibiting the SARS-CoV papain-like protease and SARS-CoV-2 MPro enzyme with an IC50 of 4200.0 nM and significant inhibition percentages at various concentrations, indicating its potential as an antiviral agent..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | 1. Neobavaisoflavone is isolated as a DNA polymerase inhibitor. 2. Neobavaisoflavone might be a potential anabolic agent to treat bone loss-associated diseases. 3. Neobavaisoflavone has anti-inflammatory activity, can significantly inhibit the production of reactive oxygen species (ROS), reactive nitrogen species (RNS) and cytokines: IL-1β, IL-6, IL-12p4, IL-12p7, TNF-α in LPS+IFN-γ- or PMA- stimulated RAW264.7 macrophages. |
| Molecular Weight | 322.35 |
| Formula | C20H18O4 |
| Cas No. | 41060-15-5 |
| Smiles | CC(C)=CCc1cc(ccc1O)-c1coc2cc(O)ccc2c1=O |
| Relative Density. | 1.279 |
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 250 mg/mL (775.55 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.2 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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