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Anti-VE-Cadherin Antibody (2K899)
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Catalog No. TMAY-00822
Alias cadherin 5, type 2 (vascular endothelium)
Anti-VE-Cadherin Antibody (2K899) is a Mouse antibody targeting VE-Cadherin. Anti-VE-Cadherin Antibody (2K899) can be used in FCM,ICC/IF.
Anti-VE-Cadherin Antibody (2K899)
Anti-VE-Cadherin Antibody (2K899)
😃Good
Catalog No. TMAY-00822Alias cadherin 5, type 2 (vascular endothelium)
Anti-VE-Cadherin Antibody (2K899) is a Mouse antibody targeting VE-Cadherin. Anti-VE-Cadherin Antibody (2K899) can be used in FCM,ICC/IF.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $198 | 7-10 days |
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Chemical Properties
| Description | Anti-VE-Cadherin Antibody (2K899) is a Mouse antibody targeting VE-Cadherin. Anti-VE-Cadherin Antibody (2K899) can be used in FCM,ICC/IF. |
| Alias | cadherin 5, type 2 (vascular endothelium) |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 2K899 |
| Reactivity | Human |
| Verified Activity | 1. Flow cytometric analysis of Human CD144 expression on HUVEC cells. Cells were stained with purified anti-Human CD144, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. 2. Immunofluorescence staining of CDH5 in HUVEC cells. Cells were fixed with 4% PFA,blocked with 10% serum, and incubated with mouse anti-human CDH5 monoclonal antibody (dilution ratio 1:30) at 4°C overnight. Then cells were stained with the Alexa Fluor®488-conjugated Goat Anti-mouse IgG secondary antibody (green). Positive staining was localized to Cell membrane. |
| Application | FCM,ICC/IF |
| Recommended Dose | ICC-IF: 1:10-1:50; FCM: 1:25-1:100 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human VE-Cadherin / CD144 / CDH5 (rh VE-Cadherin / CD144 / CDH5; CAA56306.1; Met1-Gln593). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Cadherins (Calcium dependent adhesion molecules) are a class of transmembrane proteins. Cadherin-5, also known as VE-cadherin, CDH5 and CD144, an endothelial specific cell-cell adhesion molecule, plays a pivotal role in the formation, maturation and remodeling of the vascular wall. VE-Cadherin is widely considered to be specific for vascular endothelia in which it is either the sole or the predominant cadherin, often co-existing with N-cadherin. This specificity of VE-cadherin for vascular endothelial cells is important not only in blood and lymph vessel biology and medicine, but also for cell-type-based diagnoses, notably those of metastatic tumors. As a classical cadherin, VE-Cadherin links endothelial cells together by homophilic interactions mediated by its extracellular part and associates intracellularly with the actin cytoskeleton via catenins. Mechanisms that regulate VE-cadherin-mediated adhesion are important for the control of vascular permeability and leukocyte extravasation. In addition to its adhesive functions, VE-Cadherin regulates various cellular processes such as cell proliferation and apoptosis and modulates vascular endothelial growth factor receptor functions. Consequently, VE-cadherin is essential during embryonic angiogenesis. |
| Conjucates | Unconjugated |
| Others Formats | APC/FITC/PE |
| Antibody Types Available | 4 |
| Immunogen | Recombinant Human VE-Cadherin / CD144 / CDH5 Protein |
| Antigen Species | Human |
| Biology Area | Hemangioblast Markers, Cardiac Stem Cell Markers |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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