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Salicyl alcohol

Name: Salicyl alcohol
Brand: TargetMol
SKU: T0311
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0311Cas No. 90-01-7

Alias α,2-Toluenediol, Saligenol, Saligenin, o-Methylolphenol, Diathesin, 2-Hydroxybenzyl alcohol

Salicyl alcohol is an inhibitor of lymphocyte-mediated cell lysis from prunes.

Salicyl alcohol

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Purity: 99.47%

Catalog No. T0311Alias α,2-Toluenediol, Saligenol, Saligenin, o-Methylolphenol, Diathesin, 2-Hydroxybenzyl alcoholCas No. 90-01-7

Salicyl alcohol is an inhibitor of lymphocyte-mediated cell lysis from prunes.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.47%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Salicyl alcohol AI Summary

Salicyl alcohol exhibits broad bioactivity across multiple biological systems and pathogens. It demonstrates antiviral properties against HIV-1, HIV-2, and SARS-CoV-2, with notable findings including an EC50 value greater than 250,000 nM in CEM/O cells and inhibition of SARS-CoV-2 induced cytotoxicity in Caco-2 cells by 42.59% at 10 µM. It also inhibits SARS-CoV-2 3CL-Pro protease activity by 21.91% at 20 µM. The compound shows notable inhibition of malarial parasite plastid at 1199.5 nM and blocks Ebola virus entry with AC50 values ranging from 0.631 µM to 631 nM. In cytotoxicity assays, Salicyl alcohol exhibits varying effects; it shows a CC50 value greater than 250,000 nM in CEM/O cells but demonstrates lower potency against mouse L1210 and HEK293 cells harboring the pendrin P123S mutant. It inhibits mouse L1210 cells in caspase-mediated apoptosis at 0.1 mM with under 15% activity and displays moderate cytotoxicity against HEK293 cells with an IC50 over 15,000,000 nM. Mechanistically, the compound shows high inhibition of sodium fluorescein uptake in OATP1B1 and OATP1B3-transfected CHO cells at 10 µM, indicating potent transporter inhibition. It has a logP of 0.73, suggesting moderate lipophilicity, which can influence its pharmacokinetics. Additionally, Salicyl alcohol shows a minor inhibitory effect on recombinant bovine liver ARGI enzyme (11% at 500 µM) and human HDAC6 activity, with a higher inhibition using a commercial substrate (-23.2%) compared to a custom peptide substrate (-2.56%). Overall, Salicyl alcohol’s diverse bioactivity profile highlights its potential as a therapeutic candidate across various viral, parasitic, and cellular targets..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Salicyl alcohol is an inhibitor of lymphocyte-mediated cell lysis from prunes.
Synonyms	α,2-Toluenediol, Saligenol, Saligenin, o-Methylolphenol, Diathesin, 2-Hydroxybenzyl alcohol

Chemical Properties

Molecular Weight	124.14
Formula	C₇H₈O₂
Cas No.	90-01-7
Smiles	C(O)C1=C(O)C=CC=C1
Relative Density.	1.613 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (402.77 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	8.0554 mL	40.2771 mL	80.5542 mL	402.7711 mL
5 mM	1.6111 mL	8.0554 mL	16.1108 mL	80.5542 mL
10 mM	0.8055 mL	4.0277 mL	8.0554 mL	40.2771 mL
20 mM	0.4028 mL	2.0139 mL	4.0277 mL	20.1386 mL
50 mM	0.1611 mL	0.8055 mL	1.6111 mL	8.0554 mL
100 mM	0.0806 mL	0.4028 mL	0.8055 mL	4.0277 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc