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OsMundacetone

Name: OsMundacetone
Brand: TargetMol
SKU: T5728
Price: 44 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5728Cas No. 37079-84-8

Alias 4-(3,4-Dihydroxyphenyl)-3-buten-2-one

OsMundacetone (4-(3,4-Dihydroxyphenyl)-3-buten-2-one) is a natual product isolated from Rhizoma osmundae.

OsMundacetone

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Purity: 99.59%

Catalog No. T5728Alias 4-(3,4-Dihydroxyphenyl)-3-buten-2-oneCas No. 37079-84-8

OsMundacetone (4-(3,4-Dihydroxyphenyl)-3-buten-2-one) is a natual product isolated from Rhizoma osmundae.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$44	In Stock	In Stock
5 mg	$98	In Stock	In Stock
10 mg	$166	In Stock	In Stock
25 mg	$277	In Stock	In Stock
50 mg	$397	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$93	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.59%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HNMR HPLC

Product Introduction

OsMundacetone AI Summary

OsMundacetone exhibits diverse bioactivities across multiple biological systems. It inhibits UV-induced mutagenesis in Escherichia coli WP2uvrA with an IC50 value of 977237.22 nM. It also shows inhibitory activity against the peroxidation of rabbit red blood cell membrane ghosts induced by tert-butyl hydroperoxide and gamma-ray irradiation, with IC50 values of 27542287033381.75 nM and 2338.84 nM, respectively. In cytotoxicity studies, OsMundacetone demonstrates significant activity against various human cell lines, including A549, BGC823, MCF7, Bel7402, Ketr3, and HCT8, with variable IC50 values indicating its potency in inhibiting cell growth and proliferation. Specifically, it has an IC50 value of 4700.0 nM against human Bel7402 cells but shows no significant cytotoxicity against human KB or A549 cells, with IC50 values exceeding 10,000.0 nM. Furthermore, OsMundacetone inhibits tyrosine kinase activity with an IC50 value of 7700.0 nM and human recombinant COX2 with an IC50 value of 22200.0 nM. It promotes osteoblast differentiation and inhibits osteoclast differentiation and bone resorption, suggesting potential applications in bone metabolism. The compound also protects mouse HT-22 cells against glutamate-induced cell death, with an EC50 value of 1500.0 nM, and inhibits the aggregation of islet amyloid polypeptide with an IC50 value of 3700.0 nM. These varied pharmacological effects, along with measurable pharmacokinetic properties in mice, highlight the compound's potential for further development in multiple therapeutic areas..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	OsMundacetone (4-(3,4-Dihydroxyphenyl)-3-buten-2-one) is a natual product isolated from Rhizoma osmundae.
Synonyms	4-(3,4-Dihydroxyphenyl)-3-buten-2-one

Chemical Properties

Molecular Weight	178.1846
Formula	C₁₀H₁₀O₃
Cas No.	37079-84-8
Smiles	O=C(C=CC1=CC=C(O)C(O)=C1)C
Relative Density.	1.264 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45.00 mg/mL (252.55 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.6122 mL	28.0608 mL	56.1216 mL	280.6079 mL
5 mM	1.1224 mL	5.6122 mL	11.2243 mL	56.1216 mL
10 mM	0.5612 mL	2.8061 mL	5.6122 mL	28.0608 mL
20 mM	0.2806 mL	1.4030 mL	2.8061 mL	14.0304 mL
50 mM	0.1122 mL	0.5612 mL	1.1224 mL	5.6122 mL
100 mM	0.0561 mL	0.2806 mL	0.5612 mL	2.8061 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc