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Rilpivirine

Name: Rilpivirine
Brand: TargetMol
SKU: T2330
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2330Cas No. 500287-72-9

Alias TMC278, R278474, DB08864

Rilpivirine (R278474) is a diarylpyrimidine derivative and reverse transcriptase inhibitor with antiviral activity against HIV-1 that is used in the treatment of HIV infections.

Rilpivirine

🥰Excellent

Purity: 98.83%

Catalog No. T2330Alias TMC278, R278474, DB08864Cas No. 500287-72-9

Rilpivirine (R278474) is a diarylpyrimidine derivative and reverse transcriptase inhibitor with antiviral activity against HIV-1 that is used in the treatment of HIV infections.

Pack Size	Price	Availability
2 mg	$32	In Stock
5 mg	$50	In Stock
10 mg	$80	In Stock
25 mg	$148	In Stock
50 mg	$255	In Stock
100 mg	$355	In Stock
200 mg	$526	In Stock
1 mL x 10 mM (in DMSO)	$56	In Stock

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Purity:98.83%

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Product Introduction

Bioactivity

Description	Rilpivirine (R278474) is a diarylpyrimidine derivative and reverse transcriptase inhibitor with antiviral activity against HIV-1 that is used in the treatment of HIV infections.
In vitro	Rilpivirine, dissolved in PEG 400 and administered via intravenous injection at dosages of 4 mg/kg in rats and 1.25 mg/kg in dogs, exhibits half-lives of 4.4 hours and 31 hours, respectively.
In vivo	Rilpivirine demonstrates antiviral activity against both wild-type and selective point single and double HIV-1 mutants, with an effective concentration (EC50) ranging from 0.1 to 2 nM.
Synonyms	TMC278, R278474, DB08864

Chemical Properties

Molecular Weight	366.42
Formula	C₂₂H₁₈N₆
Cas No.	500287-72-9
Smiles	N(C1=C(C)C=C(/C=C/C#N)C=C1C)C2=NC(NC3=CC=C(C#N)C=C3)=NC=C2
Relative Density.	1.27 g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (150.1 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7291 mL	13.6455 mL	27.2911 mL	136.4554 mL
5 mM	0.5458 mL	2.7291 mL	5.4582 mL	27.2911 mL
10 mM	0.2729 mL	1.3646 mL	2.7291 mL	13.6455 mL
20 mM	0.1365 mL	0.6823 mL	1.3646 mL	6.8228 mL
50 mM	0.0546 mL	0.2729 mL	0.5458 mL	2.7291 mL
100 mM	0.0273 mL	0.1365 mL	0.2729 mL	1.3646 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc