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Soticlestat

🥰Excellent
Catalog No. T8937Cas No. 1429505-03-2
Alias TAK-935, OV935

Soticlestat (OV935) is a potent, selective and orally active cholesterol 24-hydroxylase (CYP46A1) inhibitor. It has the potential for epilepsy syndromes research.

Soticlestat

Soticlestat

🥰Excellent
Purity: 99.79%
Catalog No. T8937Alias TAK-935, OV935Cas No. 1429505-03-2
Soticlestat (OV935) is a potent, selective and orally active cholesterol 24-hydroxylase (CYP46A1) inhibitor. It has the potential for epilepsy syndromes research.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$60In StockIn Stock
5 mg$147In StockIn Stock
10 mg$239In StockIn Stock
25 mg$478In StockIn Stock
50 mg$688In StockIn Stock
100 mg$996In StockIn Stock
1 mL x 10 mM (in DMSO)$162In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.79%
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Product Introduction

Bioactivity
Description
Soticlestat (OV935) is a potent, selective and orally active cholesterol 24-hydroxylase (CYP46A1) inhibitor. It has the potential for epilepsy syndromes research.
In vitro
Soticlestat inhibits the catalytic activity of human cholesterol 24-hydroxylase (CH24H) in a concentration-dependent manner with an IC50?of 4.5 nM
In vivo
Soticlestat treatment lowers brain 24S-hydroxycholesterol in a dose-dependent manner and substantially reduceds premature deaths of APP/PS1-Tg mice at a dose lowering brain 24S-hydroxycholesterol by approximately 50%. Soticlestat can suppress potassium-evoked extracellular glutamate elevations in the hippocampus
SynonymsTAK-935, OV935
Chemical Properties
Molecular Weight373.45
FormulaC23H23N3O2
Cas No.1429505-03-2
SmilesOC1(Cc2ccccc2)CCN(CC1)C(=O)c1cccnc1-c1ccncc1
Relative Density.no data available
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 100 mg/mL (267.77 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (10.71 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.6777 mL13.3887 mL26.7773 mL133.8867 mL
5 mM0.5355 mL2.6777 mL5.3555 mL26.7773 mL
10 mM0.2678 mL1.3389 mL2.6777 mL13.3887 mL
20 mM0.1339 mL0.6694 mL1.3389 mL6.6943 mL
50 mM0.0536 mL0.2678 mL0.5355 mL2.6777 mL
100 mM0.0268 mL0.1339 mL0.2678 mL1.3389 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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μL
2 Enter the in vivo formulation:
% DMSO
%
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% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

TAK935TAK 935SoticlestatOV-935OV 935NMDAInhibitorinhibitepilepsyCytochrome P450CYPsCYP46A1cholesterolantiepileptic24-hydroxylase
Related Tags: buy Soticlestat | purchase Soticlestat | Soticlestat cost | order Soticlestat | Soticlestat chemical structure | Soticlestat in vivo | Soticlestat in vitro | Soticlestat formula | Soticlestat molecular weight
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