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Nikethamide

Name: Nikethamide
Brand: TargetMol
SKU: T0048
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0048Cas No. 59-26-7

Alias N,N-Diethylnicotinamide, Corvotone, Corvin, Anacardone

Nikethamide is a stimulant which mainly influences the respiratory cycle. Widely known by its former sales name of Coramine, it was used in the mid-twentieth century as a medical countermeasure against tranquilizer overtreatments, before the advent of endotracheal intubation and positive-pressure lung expansion. It is now thought to be of no value for such purposes, and may be dangerous.

Nikethamide

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Purity: 99.42%

Catalog No. T0048Alias N,N-Diethylnicotinamide, Corvotone, Corvin, AnacardoneCas No. 59-26-7

Pack Size	Price	USA Warehouse	Global Warehouse
500 mg	$40	-	In Stock
1 g	$50	-	In Stock
5 g	$113	Inquiry	Inquiry
10 g	$166	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$30	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.42%

Appearance:Liquid

Color:Transparent

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Nikethamide is a stimulant which mainly influences the respiratory cycle. Widely known by its former sales name of Coramine, it was used in the mid-twentieth century as a medical countermeasure against tranquilizer overtreatments, before the advent of endotracheal intubation and positive-pressure lung expansion. It is now thought to be of no value for such purposes, and may be dangerous.
Synonyms	N,N-Diethylnicotinamide, Corvotone, Corvin, Anacardone

Chemical Properties

Molecular Weight	178.23
Formula	C₁₀H₁₄N₂O
Cas No.	59-26-7
Smiles	CCN(CC)C(=O)c1cccnc1
Relative Density.	1.06g/mLat 25°C(lit.)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (252.48 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.6107 mL	28.0536 mL	56.1073 mL	280.5364 mL
5 mM	1.1221 mL	5.6107 mL	11.2215 mL	56.1073 mL
10 mM	0.5611 mL	2.8054 mL	5.6107 mL	28.0536 mL
20 mM	0.2805 mL	1.4027 mL	2.8054 mL	14.0268 mL
50 mM	0.1122 mL	0.5611 mL	1.1221 mL	5.6107 mL
100 mM	0.0561 mL	0.2805 mL	0.5611 mL	2.8054 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc