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Anti-iNOS Polyclonal Antibody
(Synonyms: NOS2A, NOS2, NOS type II, Nos II, NOS 2A, NOS 2, NOS, Nitric Oxide Synthase, Inducible, Nitric oxide synthase inducible, Nitric oxide synthase 2A(inducible hepatocytes), Nitric oxide synthase 2 inducible macrophage, Macrophage NOS, MAC NOS, Inosl, INOS, Inducible NOS, Inducible NO synthase, Inducible nitric oxide synthase, i NOS, HEPNOS, Hepatocyte NOS, HEP NOS) Copy Product Info
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Synonyms: NOS2A, NOS2, NOS type II, Nos II, NOS 2A, NOS 2, NOS, Nitric Oxide Synthase, Inducible, Nitric oxide synthase inducible, Nitric oxide synthase 2A(inducible hepatocytes), Nitric oxide synthase 2 inducible macrophage, Macrophage NOS, MAC NOS, Inosl, INOS, Inducible NOS, Inducible NO synthase, Inducible nitric oxide synthase, i NOS, HEPNOS, Hepatocyte NOS, HEP NOS
Catalog No. TMAB-00970 Copy Product Info
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Anti-iNOS Polyclonal Antibody is a Rabbit antibody targeting iNOS. Anti-iNOS Polyclonal Antibody can be used in ELISA, IF, IHC-Fr, IHC-P, WB.
Anti-iNOS Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $221 | 7-10 days | 7-10 days | |
| 100 μL | $372 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:1mg/ml
Appearance:Liquid
Color:Transparent
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| Description | Anti-iNOS Polyclonal Antibody is a Rabbit antibody targeting iNOS. Anti-iNOS Polyclonal Antibody can be used in ELISA, IF, IHC-Fr, IHC-P, WB. |
| Synonyms | NOS2A, NOS2, NOS type II, Nos II, NOS 2A, NOS 2, NOS, Nitric Oxide Synthase, Inducible, Nitric oxide synthase inducible, Nitric oxide synthase 2A(inducible hepatocytes), Nitric oxide synthase 2 inducible macrophage, Macrophage NOS, MAC NOS, Inosl, INOS, Inducible NOS, Inducible NO synthase, Inducible nitric oxide synthase, i NOS, HEPNOS, Hepatocyte NOS, HEP NOS |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat |
| Application | |
| Recommended Dose | ELISA=1:5000-10000; IF=1:100-500; IHC-Fr=1:100-500; IHC-P=1:100-500; WB=1:1000-5000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytosol |
| Tissue Specificity | Expressed in the liver, retina, bone cells and airway epithelial cells of the lung. Not expressed in the platelets. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | Nitric oxide (NO) is an inorganic, gaseous free radical that carries a variety of messages between cells. Vasorelaxation, neurotransmission and cytotoxicity can all be potentiated through cellular response to NO. NO production is mediated by members of the nitric oxide synthase (NOS) family. NOS catalyzes the oxidization of L-arginine to produce L-citrulline and NO. Two constitutive isoforms, brain or neuronal NOS (b or nNOS, type I) & endothelial cell NOS (eNOS, type III), and one inducible isoform (iNOS, type II), have been cloned. All NOS isoforms contain calmodulin, nicotinamide adenine dinucleotide phosphate (NADPH), flavin adenine dinucleotide (FAD), and flavin mononucleotide (FMN) binding domains. Nitric oxide synthase is expressed in liver, macrophages, hepatocytes, synoviocytes, stimulated glial cells and smooth muscle cells. Cytokines such as interferon-gamma (IFN), tumor necrosis factor (TNF), interleukin-1 and -2, and lipopolysaccarides (LPS) cause an increase in iNOS mRNA, protein, and activity levels. Protein kinase C-stimulating agents exhibit the same effect on iNOS activity. After cytokine induction, iNOS exhibits a delayed activity response which is then followed by a significant increase in NO production over a long period of time. Human iNOS is regulated by calcium/calmodulin (in contrast with mouse NOS2). |
| Immunogen | KLH conjugated synthetic peptide: human NOS-2 |
| Antigen Species | Human |
| Gene Name | NOS2 |
| Gene ID | |
| Protein Name | Nitric oxide synthase, inducible |
| Uniprot ID | |
| Biology Area | Cellular metabolic process,Response to hypoxia,Hypoxia,NOS |
| Function | Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2. |
| Molecular Weight | Theoretical: 130 kDa. Actual: 130 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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