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Dibenzosuberone

Name: Dibenzosuberone
Brand: TargetMol
SKU: T0559
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0559Cas No. 1210-35-1

Dibenzosuberone, pharmaceutical intermediates, is used for the synthesis of drug amitriptyline.

Dibenzosuberone

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Purity: 99.83%

Catalog No. T0559Cas No. 1210-35-1

Dibenzosuberone, pharmaceutical intermediates, is used for the synthesis of drug amitriptyline.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
10 g	$29	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.83%

Color:White

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COA HNMR LCMS

Product Introduction

Dibenzosuberone AI Summary

Dibenzosuberone exhibits a variety of bioactivities across multiple assays. It has a potency of 56234.1 nM for inhibiting HP1-beta Chromodomain interactions with Methylated Histone Tails and a potency of 89125.1 nM as an inhibitor of Regulator of G Protein Signaling (RGS) 4. Notably, it demonstrates efficacy in blocking the entry of the Ebola Virus, with an AC50 of 3162.3 nM in a qHTS assay, 14.13 μM and 3.162 μM in different screening assays, and 14125.4 nM in a separate assay..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Dibenzosuberone, pharmaceutical intermediates, is used for the synthesis of drug amitriptyline.

Chemical Properties

Molecular Weight	208.26
Formula	C₁₅H₁₂O
Cas No.	1210-35-1
Smiles	O=C1C2=C(CCC3=C1C=CC=C3)C=CC=C2
Relative Density.	1.156

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (264.09 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.8017 mL	24.0085 mL	48.0169 mL	240.0845 mL
5 mM	0.9603 mL	4.8017 mL	9.6034 mL	48.0169 mL
10 mM	0.4802 mL	2.4008 mL	4.8017 mL	24.0085 mL
20 mM	0.2401 mL	1.2004 mL	2.4008 mL	12.0042 mL
50 mM	0.0960 mL	0.4802 mL	0.9603 mL	4.8017 mL
100 mM	0.0480 mL	0.2401 mL	0.4802 mL	2.4008 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc