Anti-RANKL/TNFSF11/CD254 Polyclonal Antibody

Name: Anti-RANKL/TNFSF11/CD254 Polyclonal Antibody
Brand: TargetMol
SKU: TMAB-01609
Rating: 4.5 (1 reviews)

(Synonyms: tumor necrosis factor ligand superfamily member 11, TNFSF11, Receptor activator of nuclear factor κ-B ligand, Receptor activator of nuclear factor kappa-B ligand, RANK L, Osteoclast differentiation factor, OPGL, ODF, CD254) Copy Product Info

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Synonyms: tumor necrosis factor ligand superfamily member 11, TNFSF11, Receptor activator of nuclear factor κ-B ligand, Receptor activator of nuclear factor kappa-B ligand, RANK L, Osteoclast differentiation factor, OPGL, ODF, CD254

Catalog No. TMAB-01609 Copy Product Info

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Anti-RANKL/TNFSF11/CD254 Polyclonal Antibody is a Rabbit antibody targeting RANKL/TNFSF11/CD254. Anti-RANKL/TNFSF11/CD254 Polyclonal Antibody can be used in FCM,IF,IHC-Fr,IHC-P,WB.

Anti-RANKL/TNFSF11/CD254 Polyclonal Antibody

Pack Size	Price	USA Stock	Global Stock
50 μL	$220	7-10 days	7-10 days
100 μL	$372	7-10 days	7-10 days
200 μL	$528	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Instruction Manual of Detection Antibody

Product Introduction

Bioactivity

Description	Anti-RANKL/TNFSF11/CD254 Polyclonal Antibody is a Rabbit antibody targeting RANKL/TNFSF11/CD254. Anti-RANKL/TNFSF11/CD254 Polyclonal Antibody can be used in FCM,IF,IHC-Fr,IHC-P,WB.
Synonyms	tumor necrosis factor ligand superfamily member 11, TNFSF11, Receptor activator of nuclear factor κ-B ligand, Receptor activator of nuclear factor kappa-B ligand, RANK L, Osteoclast differentiation factor, OPGL, ODF, CD254
Ig Type	IgG
Reactivity	Human,Mouse (predicted:Rat,Dog)

Application	FCM IF IHC-Fr IHC-P WB
Recommended Dose	WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500; FCM: 1μg/Test
Antibody Type	Polyclonal
Host Species	Rabbit
Subcellular Localization	Cytoplasm; Secreted and Cell membrane.
Tissue Specificity	Highest in the peripheral lymph nodes, weak in spleen, peripheral blood Leukocytes, bone marrow, heart, placenta, skeletal muscle, stomach and thyroid.
Construction	Polyclonal Antibody
Purification	Protein A purified
Appearance	Liquid
Formulation	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration	1 mg/mL
Research Background	This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008].

Antigen Details

Immunogen	KLH conjugated synthetic peptide: human OPGL
Antigen Species	Human
Gene Name	TNFSF11
Gene ID	8600
Protein Name	Tumor necrosis factor ligand superfamily member 11
Uniprot ID	O14788
Biology Area	Thrombosis,Regulatory T Cells,TNF Superfamily
Function	Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.