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Protease Inhibitor Library

Catalog No. L1100
  Library Compound List   Excel SDF

Protease inhibitors are molecules that inhibit the function of proteases (enzymes that aid the breakdown of proteins), including proteins protease inhibitors, natural protease inhibitors, and synthetic protease inhibitors. (1). Antiprotozoal activity: protease inhibitors could be used against malaria and gastrointestinal protozoal infections; (2). Antiretrovirals: protease inhibitors were the second class of antiretroviral drugs developed widely used to treat HIV/AIDS and hepatitis C; (3). Anticancer activity: Researchers are investigating whether protease inhibitors could possibly be used to treat cancer. For example, nelfinavir and atazanavir are able to kill tumor cells in culture. Inhibitors of the proteasome, such as bortezomib are now front-line drugs for the treatment of multiple myeloma. Marimastat and batimastat are two of the matrix metalloproteinase inhibitors that can be used to treat cancer.

The Protease Inhibitor Library by TargetMol, containing 344 small protease and proteasome inhibitors, can be used for research in Chemical Genomics and drug screening.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Compound Libraries | TargetMol
Pack Size
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)
If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at inquiry@targetmol.com
Request Library
Get quote

Product Description

  • A unique collection of 344 protease and proteasome inhibitors for research in chemical genomics, and drug screening;
  • Targets include proteasome, DPP-4, Serine protease, cysteine protease, MMP, Aspartic proteinases, etc;
  • Bioactivity and safety confirmed by pre-clinical research and clinical trials, and some of them are approved by FDA;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice

Supporting Files

Library Handling Instructions (635 KB) Targetmol Library Catalog (13.2 MB) Request for Library Compostion in Excel and SDF files
Request Library Compound List (L1100)

Publications Cited TargetMol Libraries

1. Journal of Neuroinflammation. 18.1 (2021): 1-22. 2. American Journal of Cancer Research. 2020, 10(8): 2535. 3. Journal of Virology. 2018, 92(2): e01582-17. 4. Journal of Virology. 2019: JVI. 01208-19. 5. Disease Models & Mechanisms. 2023. 6. Cell Stem Cell. 2022 Apr 29(4) 545–558. 7. Science Bulletin. 2022. 8. Science Translational Medicine. 2022, 14(656): eabn3231. 9. Science Advances. 2023, 9(9): eade3760.
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Library Composition

MMP (57)
Proteasome (49)
Tyrosinase (48)
Caspase (47)
Apoptosis (45)
Autophagy (31)
HIV Protease (29)
Gamma-secretase (29)
Cysteine Protease (28)
Serine Protease (24)
SARS-CoV (24)
DPP-4 (23)
Antibacterial (20)
Thrombin (17)
HCV Protease (14)
Endogenous Metabolite (12)
NF-κB (11)
BCL (9)
p38 MAPK (8)
Beta Amyloid (8)
Parasite (8)
PARP (8)
COX (8)
Serine/threonin kinase (7)
TNF (7)
ERK (6)
Virus Protease (6)
PPAR (6)
Akt (6)
P450 (5)
BACE (5)
Glutaminase (5)
Ferroptosis (4)
P-gp (4)
Reactive Oxygen Species (4)
VEGFR (4)
GABA Receptor (4)
Influenza Virus (4)
Factor Xa (4)
Antifungal (4)
AMPK (4)
Antibiotic (4)
Beta-Secretase (4)
Interleukin (3)
IL Receptor (3)
JNK (3)
Prostaglandin Receptor (3)
Antioxidant (3)
Mitophagy (3)
AChR (3)
Anti-infection (3)
DUB (3)
HSV (3)
Histamine Receptor (3)
transporter (3)
HDAC (3)
Lipoxygenase (3)
Platelet aggregation (2)
PI3K (2)
Free radical scavengers (2)
5-HT Receptor (2)
Potassium Channel (2)
CDK (2)
ribosome (2)
Sodium Channel (2)
Estrogen/progestogen Receptor (2)
PAI-1 (2)
Phosphatase (2)
Drug Metabolite (2)
NO Synthase (2)
IAP (2)
Immunology/Inflammation related (2)
c-Kit (1)
IGF-1R (1)
Glucosidase (1)
EGFR (1)
Sirtuin (1)
Src (1)
STAT (1)
TLR (1)
Amino Acids and Derivatives (1)
Topoisomerase (1)
HER (1)
ALK (1)
Tyrosine Kinases (1)
UGT (1)
Adrenergic Receptor (1)
ROR (1)
Ras (1)
IκB/IKK (1)
DNA (1)
p53 (1)
Calcium Channel (1)
CXCR (1)
PDGFR (1)
Aurora Kinase (1)
Na+/Ca2+ Exchanger (1)
Phospholipase (1)
PKC (1)
CaMK (1)
Microtubule Associated (1)
MAPK (1)
ATPase (1)
JAK (1)
Protease (1)
Antiviral (1)
Proton pump (1)
Pyroptosis (1)
E1/E2/E3 Enzyme (1)

Library Information Sample

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE
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