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Rimacalib

Name: Rimacalib
Brand: TargetMol
SKU: T16752
Rating: 4.5 (1 reviews)

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Catalog No. T16752Cas No. 215174-50-8

Alias SMP 114

Rimacalib is an inhibitor of Ca2+/calmodulin-dependent protein kinase II (IC50s: ~1 μM for CaMKIIα and ~30 μM for CaMKIIγ).

Rimacalib

😃Good

Catalog No. T16752Alias SMP 114Cas No. 215174-50-8

Rimacalib is an inhibitor of Ca2+/calmodulin-dependent protein kinase II (IC50s: ~1 μM for CaMKIIα and ~30 μM for CaMKIIγ).

Pack Size	Price	Availability
25 mg	$1,520	6-8 weeks
50 mg	$1,980	6-8 weeks
100 mg	$2,500	6-8 weeks

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Product Introduction

Bioactivity

Description	Rimacalib is an inhibitor of Ca2+/calmodulin-dependent protein kinase II (IC50s: ~1 μM for CaMKIIα and ~30 μM for CaMKIIγ).
Targets&IC50	CaMK IIα:1 μM, CaMK IIγ:30 μM
In vitro	Higher Fura-2 transient amplitude after the pause upon Rimacalib vs. 37.2±4.3% in control and in parallel cardiomyocyte contractility (135.0±15.4% vs. 97.2±16% increase of twitch amplitude, p=0.098). Rimacalib improves (by ~40%) Ca2+-transient potentiation during the 30 s stimulation pause [1].
Synonyms	SMP 114

Chemical Properties

Molecular Weight	394.44
Formula	C₂₂H₂₃FN₄O₂
Cas No.	215174-50-8
Relative Density.	1.29 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (316.90 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5352 mL	12.6762 mL	25.3524 mL	126.7620 mL
5 mM	0.5070 mL	2.5352 mL	5.0705 mL	25.3524 mL
10 mM	0.2535 mL	1.2676 mL	2.5352 mL	12.6762 mL
20 mM	0.1268 mL	0.6338 mL	1.2676 mL	6.3381 mL
50 mM	0.0507 mL	0.2535 mL	0.5070 mL	2.5352 mL
100 mM	0.0254 mL	0.1268 mL	0.2535 mL	1.2676 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc