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6-Acetamidohexanoic acid

Name: 6-Acetamidohexanoic acid
Brand: TargetMol
SKU: T0436
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0436Cas No. 57-08-9

Alias Acexamic Acid, 6-Acetamidocaproic acid

6-Acetamidohexanoic acid (Acexamic Acid) is a kind of amino acids deriviate.

6-Acetamidohexanoic acid

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Purity: 99.87%

Catalog No. T0436Alias Acexamic Acid, 6-Acetamidocaproic acidCas No. 57-08-9

6-Acetamidohexanoic acid (Acexamic Acid) is a kind of amino acids deriviate.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.87%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

6-Acetamidohexanoic acid AI Summary

6-Acetamidohexanoic acid demonstrates a range of bioactivities, particularly in inhibiting sodium fluorescein uptake in OATP1B3 and OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 µM, with inhibition percentages of 111.28% and 144.21%, respectively. The compound exhibits notable antiviral properties, including blocking the entry of the Ebola and potentially the Foot and Mouth Disease viruses, with AC50 values ranging from 1122.0 nM to 1.585 µM. Additionally, 6-Acetamidohexanoic acid inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 cells by 55.22% at 10 µM after 48 hours, and shows moderate effectiveness against SARS-CoV-2 (USA-WA1/2020 strain) in HRCE cells with a hit score of 0.3113. However, its inhibitory activity against the SARS-CoV-2 3CL-Pro protease is minimal at -2.253% at 20 µM. Furthermore, it exhibits limited activity in VERO-6 cells, with inhibition rates of 0.14% and IC50 values exceeding 20000.0 nM. 6-Acetamidohexanoic acid also inhibits the human HDAC6 enzyme by 31.78% with a commercial peptide substrate, but its activity decreases to -7.1% with a custom peptide substrate. Despite being evaluated for various bioactivities related to multiple human receptors and enzymes, it does not show significant activity in those assays (AC50 > 30000.0 nM)..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	6-Acetamidohexanoic acid (Acexamic Acid) is a kind of amino acids deriviate.
Synonyms	Acexamic Acid, 6-Acetamidocaproic acid

Chemical Properties

Molecular Weight	173.21
Formula	C₈H₁₅NO₃
Cas No.	57-08-9
Smiles	C(CC(O)=O)CCCNC(C)=O
Relative Density.	1.1599 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 1.8 mg/mL (10.39 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (5.77 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.7733 mL	28.8667 mL	57.7334 mL	288.6669 mL
5 mM	1.1547 mL	5.7733 mL	11.5467 mL	57.7334 mL
10 mM	0.5773 mL	2.8867 mL	5.7733 mL	28.8667 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc