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Anti-L-selectin Antibody-PE (5Y880)
🥰Excellent
Catalog No. TMAY-03059P
Anti-L-selectin Antibody-PE (5Y880) is a PE-conjugated Rabbit antibody targeting L-selectin. Anti-L-selectin Antibody-PE (5Y880) can be used in FCM.
Anti-L-selectin Antibody-PE (5Y880)
Anti-L-selectin Antibody-PE (5Y880)
🥰Excellent
Catalog No. TMAY-03059P
Anti-L-selectin Antibody-PE (5Y880) is a PE-conjugated Rabbit antibody targeting L-selectin. Anti-L-selectin Antibody-PE (5Y880) can be used in FCM.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-L-selectin Antibody-PE (5Y880) is a PE-conjugated Rabbit antibody targeting L-selectin. Anti-L-selectin Antibody-PE (5Y880) can be used in FCM. |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 5Y880 |
| Reactivity | Mouse |
| Verified Activity | Flow cytometric analysis of CD62L expression on spleen lymphocytes. |
| Application | FCM |
| Recommended Dose | 10 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse SELL / CD62L / L-selectin (rM SELL / CD62L / L-selectin; TMPY-01184; NP_035476.1; Met 1-Asn 332) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| Research Background | L-selectin (SELL), also known as CD62L, is a key adhesion molecule that regulates both the migration of leukocytes at sites of inflammation and the recirculation of lymphocytes between blood and lymphoid tissues. It belongs to the selectin family of proteins, and consisting of a large, highly glycosylated, extracellular domain, a single spanning transmembrane domain and a small cytoplasmic tail. L-selectin is the only selectin expressed on leukocytes and mediates a number of leukocyte-endothelial interactions. L-selectin acts as a "homing receptor" for leukocytes to enter secondary lymphoid tissues via high endothelial venules. Ligands present on endothelial cells will bind to leukocyte expressing L-selectin, slowing leukocyte trafficking through the blood, and facilitating entry into a secondary lymphoid organ at that point. L-selectin-mediated lymphocyte recirculation is required for maintaining the appropriate tissue distribution of lymphocyte subpopulations including naïve and effector subsets such as regulatory T cells. In addition, L-selectin-mediated entry into peripheral lymph nodes is required for optimal induction of lymphocyte homeostatic proliferation during lymphopenia. Importantly, L-selectin has been shown to have both adhesive and signaling functions during leukocyte migration. L-selectin has also been shown to mediate leukocyte recruitment during chronic inflammatory and autoimmune diseases and thus is a potential therapeutic target for drug development. |
| Conjucates | PE |
| Others Formats | Unconjugated/APC/PerCP/FITC |
| Antibody Types Available | 5 |
| Immunogen | Recombinant Mouse SELL / CD62L / L-selectin protein (TMPY-01184) |
| Antigen Species | Mouse |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| Transport | Shipping with blue ice. |
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