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Sonidegib diphosphate

Name: Sonidegib diphosphate
Brand: TargetMol
SKU: T15727
Price: 43 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15727Cas No. 1218778-77-8

Alias NVP-LDE 225 diphosphate, LDE225 diphosphate, Erismodegib diphosphate

Sonidegib diphosphate (LDE225 diphosphate) is a selective antagonist of Smo that inhibits murine Smo (IC50:1.3 nM) and human Smo (IC50:2.5 nM).

Sonidegib diphosphate

🥰Excellent

Purity: 99.48%

Catalog No. T15727Alias NVP-LDE 225 diphosphate, LDE225 diphosphate, Erismodegib diphosphateCas No. 1218778-77-8

Sonidegib diphosphate (LDE225 diphosphate) is a selective antagonist of Smo that inhibits murine Smo (IC50:1.3 nM) and human Smo (IC50:2.5 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$43	In Stock	In Stock
10 mg	$52	In Stock	In Stock
25 mg	$83	In Stock	In Stock
50 mg	$116	In Stock	In Stock
100 mg	$198	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$66	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.48%

Appearance:Solid

Color:White

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COA HNMR HPLC LCMS

Product Introduction

Bioactivity

Description	Sonidegib diphosphate (LDE225 diphosphate) is a selective antagonist of Smo that inhibits murine Smo (IC50:1.3 nM) and human Smo (IC50:2.5 nM).
Targets&IC50	Smo (mouse):1.3 nM (IC50), Smo:2.5 nM (IC50)
In vitro	METHODS: Sonidegib diphosphate (LDE225 diphosphate) (10, 100nM, 72 hours) was treated in CD34 CP-CML cells and its effect on GLI1 expression in CD34 CP-CML cells was assessed. RESULTS No changes in GLI1 were observed in CD34 CP-CML cells at 6 and 24 h; at 72 h, GLI1 was significantly downregulated (10 nM; 0.78-fold and 100 nM; 0.73-fold). [2]
In vivo	METHODS: A transgenic EGFP/SCLtTA/TRE-BCR-ABL mouse model was used, and mice were treated with nilotinib (50 mg/kg, gavage, daily, 3 weeks), Sonidegib diphosphate (LDE225 diphosphate) (80 mg / kg, gavage, daily, 3 weeks), Sonidegib diphosphate (LDE225 diphosphate) + nilotinib, or carrier alone (control) treatment, to study the effects of Sonidegib diphosphate (LDE225 diphosphate) treatment on CML LSC in vivo. RESULTS The cohort treated with Sonidegib diphosphate (LDE225 diphosphate) had a small, non-significant incremental reduction in mean body weight; Sonidegib diphosphate (LDE225 diphosphate) alone reduced splenic LTHSC but did not significantly reduce GMP and CMP ; Sonidegib diphosphate (LDE225 diphosphate) + nilotinib significantly reduced GMP, CMP, and LTHSC in the spleen. in contrast, in the BM of mice treated with Sonidegib diphosphate (LDE225 diphosphate), nilotinib, or the combination there were no significant changes in the amounts of GMP, CMP and LTHSC. [2]
Synonyms	NVP-LDE 225 diphosphate, LDE225 diphosphate, Erismodegib diphosphate

Chemical Properties

Molecular Weight	681.49
Formula	C₂₆H₃₂F₃N₃O₁₁P₂
Cas No.	1218778-77-8
Smiles	OP(O)(O)=O.OP(O)(O)=O.C[C@H]1CN(C[C@@H](C)O1)c1ccc(NC(=O)c2cccc(-c3ccc(OC(F)(F)F)cc3)c2C)cn1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 99 mg/mL (145.27 mM), Sonication is recommended.

H2O: Insoluble

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (4.84 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4674 mL	7.3369 mL	14.6737 mL	73.3686 mL
5 mM	0.2935 mL	1.4674 mL	2.9347 mL	14.6737 mL
10 mM	0.1467 mL	0.7337 mL	1.4674 mL	7.3369 mL
20 mM	0.0734 mL	0.3668 mL	0.7337 mL	3.6684 mL
50 mM	0.0293 mL	0.1467 mL	0.2935 mL	1.4674 mL
100 mM	0.0147 mL	0.0734 mL	0.1467 mL	0.7337 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc