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Anti-KRT19 Antibody (6A728)
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Catalog No. TMAY-00118
Anti-KRT19 Antibody (6A728) is a Mouse antibody targeting KRT19. Anti-KRT19 Antibody (6A728) can be used in IHC-P.
Anti-KRT19 Antibody (6A728)
Anti-KRT19 Antibody (6A728)
😃Good
Catalog No. TMAY-00118
Anti-KRT19 Antibody (6A728) is a Mouse antibody targeting KRT19. Anti-KRT19 Antibody (6A728) can be used in IHC-P.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $198 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-KRT19 Antibody (6A728) is a Mouse antibody targeting KRT19. Anti-KRT19 Antibody (6A728) can be used in IHC-P. |
| Ig Type | Monoclonal Mouse IgG3 |
| Clone | 6A728 |
| Reactivity | Human |
| Verified Activity | 1. Immunochemical staining of human KRT19 in human thyroid cancer with mouse monoclonal antibody (1:500, formalin-fixed paraffin embedded sections). 2. Immunochemical staining of human KRT19 in human liver with mouse monoclonal antibody (1:500, formalin-fixed paraffin embedded sections). 3. Immunochemical staining of human KRT19 in human hepatoma with mouse monoclonal antibody (1:500, formalin-fixed paraffin embedded sections). |
| Application | IHC-P |
| Recommended Dose | IHC-P: 1:250-1:1000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with a synthetic peptide corresponding to the center region of the Human KRT19. The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Cytokeratin 19 (KRT19) is a cytoplasmic intermediate filament protein, which is responsible for structural rigidity and multipurpose scaffolds. In several cancers, KRT19 is overexpressed and may play a crucial role in tumorigenic transformation. The KRT19 gene encodes cytokeratin 19, an element of the cytoskeleton whose expression is frequently altered in renal cell carcinoma (RCC).KRT19 was identified as one of the key biomarkers for distinguishing cholangiocarcinoma (CCA) and hepatocellular carcinoma. Expression of KRT19 was specifically high in breast cancers and significantly correlated with their invasiveness. Moreover, knockdown of KRT19 led to increased proliferation, migration, invasion, drug resistance, and sphere formation in breast cancer cells via an upregulated NOTCH signaling pathway. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide corresponding to the center region of the Human KRT19 |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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