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Esmolol hydrochloride

Name: Esmolol hydrochloride
Brand: TargetMol
SKU: T1503
Rating: 4.5 (1 reviews)

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Catalog No. T1503Cas No. 81161-17-3

Alias Esmolol HCl, ASL8052

Esmolol is a cardioselective beta-blocker used in parenteral forms in the treatment of arrhythmias and severe hypertension. Esmolol has not been linked to instances of clinically apparent drug induced liver injury.

Esmolol hydrochloride

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Purity: 99.48%

Catalog No. T1503Alias Esmolol HCl, ASL8052Cas No. 81161-17-3

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$1,520	4-6 weeks	4-6 weeks
50 mg	$1,980	4-6 weeks	4-6 weeks
100 mg	$2,500	4-6 weeks	4-6 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.48%

Appearance:solid

Color:White

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COA

Product Introduction

Bioactivity

Description	Esmolol is a cardioselective beta-blocker used in parenteral forms in the treatment of arrhythmias and severe hypertension. Esmolol has not been linked to instances of clinically apparent drug induced liver injury.
In vitro	The main active site of Esmolol is the sinus node and AV node conduction system, and Esmolol has a rapid onset of action and inactivation.
In vivo	The main active site of Esmolol is the sinus node and AV node conduction system, and Esmolol has a rapid onset of action and inactivation.
Synonyms	Esmolol HCl, ASL8052

Chemical Properties

Molecular Weight	331.15
Formula	C₁₆H₂₅NO₄·HCl
Cas No.	81161-17-3
Smiles	c1(ccc(cc1)CCC(=O)OC)OCC(CNC(C)C)O.Cl
Relative Density.	1.026

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 198.9 mM, Sonication is recommended.

H2O: 150.68 mM, Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 1 mg/mL (3.02 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0198 mL	15.0989 mL	30.1978 mL	150.9890 mL
5 mM	0.6040 mL	3.0198 mL	6.0396 mL	30.1978 mL
10 mM	0.3020 mL	1.5099 mL	3.0198 mL	15.0989 mL
20 mM	0.1510 mL	0.7549 mL	1.5099 mL	7.5494 mL
50 mM	0.0604 mL	0.3020 mL	0.6040 mL	3.0198 mL
100 mM	0.0302 mL	0.1510 mL	0.3020 mL	1.5099 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc