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Darutigenol

Name: Darutigenol
Brand: TargetMol
SKU: T3817
Price: 358 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3817Cas No. 5940-00-1

Darutigenol has obvious antithrombotic effect, its mechanism may be related to inhibition of platelet aggregation and adhesion.

Darutigenol

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Purity: 99.81%

Catalog No. T3817Cas No. 5940-00-1

Darutigenol has obvious antithrombotic effect, its mechanism may be related to inhibition of platelet aggregation and adhesion.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$97	-	In Stock
2 mg	$143	-	In Stock
5 mg	$238	-	In Stock
10 mg	$358	-	In Stock
25 mg	Preferential	-	In Stock
50 mg	Preferential	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$246	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.81%

Appearance:Solid

Color:White

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COA LCMS

Product Introduction

Darutigenol AI Summary

Darutigenol exhibits a range of biological activities, including moderate cytotoxicity against human HeLa cells with an IC50 value greater than 100.0 µg/mL, as determined by the MTT assay after 44 hours. It also demonstrates anti-inflammatory properties by inhibiting LPS-induced nitric oxide production in mouse RAW264.7 cells, with an IC50 greater than 100,000.0 nM after 24 hours. Additionally, Darutigenol shows anti-invasive effects by inhibiting EGF-induced cell invasion in human MDA-MB-231 cells, with IC50 values greater than 10,000.0 nM and 25,000.0 nM reported for different durations of 3.5 hours and 24 hours, respectively. Moreover, it inhibits human coagulation factor 10a with an IC50 of 11,418.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Darutigenol has obvious antithrombotic effect, its mechanism may be related to inhibition of platelet aggregation and adhesion.

Chemical Properties

Molecular Weight	322.48
Formula	C₂₀H₃₄O₃
Cas No.	5940-00-1
Smiles	C[C@]12[C@]3(C(=C[C@]([C@H](CO)O)(C)CC3)CC[C@@]1(C(C)(C)[C@H](O)CC2)[H])[H]
Relative Density.	1.406 g/cm3

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (186.06 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1010 mL	15.5048 mL	31.0097 mL	155.0484 mL
5 mM	0.6202 mL	3.1010 mL	6.2019 mL	31.0097 mL
10 mM	0.3101 mL	1.5505 mL	3.1010 mL	15.5048 mL
20 mM	0.1550 mL	0.7752 mL	1.5505 mL	7.7524 mL
50 mM	0.0620 mL	0.3101 mL	0.6202 mL	3.1010 mL
100 mM	0.0310 mL	0.1550 mL	0.3101 mL	1.5505 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc