keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Acetyl Gastric Inhibitory Peptide (human) TFA, a fatty acid-derivatized analog of the glucose-dependent insulinotropic polypeptide, exhibits enhanced antihyperglycemic and insulinotropic properties. It is utilized in the research of diabetes, insulin resistance, and obesity [1] [2] [3].
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5 mg | Inquiry | Inquiry | |
50 mg | Inquiry | Inquiry |
Description | Acetyl Gastric Inhibitory Peptide (human) TFA, a fatty acid-derivatized analog of the glucose-dependent insulinotropic polypeptide, exhibits enhanced antihyperglycemic and insulinotropic properties. It is utilized in the research of diabetes, insulin resistance, and obesity [1] [2] [3]. |
In vitro | Acetyl Gastric Inhibitory Peptide (human) TFA induces cyclic adenosine monophosphate (cAMP) production in transfected Chinese hamster lung fibroblasts that express human GIP receptors, with an EC50 value of 1.9 nM [1]. Compared to natural GIP, Acetyl Gastric Inhibitory Peptide (human) TFA at concentrations ranging from 10-13 to 10-8 nM demonstrates potent effects in stimulating insulin release [1]. This compound can improve conditions such as glucose intolerance, type 2 diabetes, beta-cell glucose insensitivity, insulin resistance, and reduced insulin secretion [2]. Acetyl Gastric Inhibitory Peptide (human) TFA has the metabolic stability of two fatty acid-derived N-terminal acetylated GIP analogues, along with hypoglycemic and insulinotropic activities, and has been evaluated both in vitro and in vivo [3]. |
In vivo | Acetyl Gastric Inhibitory Peptide (human) TFA administered at 25 nmol/kg via intraperitoneal injection as a single dose demonstrated resistance to degradation by plasma dipeptidyl peptidase IV, thereby enhancing its bioactivity and improving its potential as an antidiabetic agent in vivo [1]. |
Synonyms | Human N-acetyl GIP TFA |
Molecular Weight | N/A |
Formula | C228H340N60O67S.C2HF3O2 |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Acetyl Gastric Inhibitory Peptide (human) TFA Human N-acetyl GIP TFA Acetyl Gastric Inhibitory Peptide Acetyl Gastric Inhibitory Peptide TFA inhibitor inhibit