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9-amino-CPT

🥰Excellent
Catalog No. T3S1957Cas No. 91421-43-1
Alias Aminocamptothecin, 9-Aminocamptothecin, 9-amino-2(S)-camptothecin

9-amino-CPT (Aminocamptothecin) is an inhibitor of topoisomerase I with potent anticancer activity.

9-amino-CPT

9-amino-CPT

🥰Excellent
Purity: 99.82%
Catalog No. T3S1957Alias Aminocamptothecin, 9-Aminocamptothecin, 9-amino-2(S)-camptothecinCas No. 91421-43-1
9-amino-CPT (Aminocamptothecin) is an inhibitor of topoisomerase I with potent anticancer activity.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$35In StockIn Stock
2 mg$48In StockIn Stock
5 mg$93In StockIn Stock
10 mg$147In StockIn Stock
25 mg$263In StockIn Stock
50 mg$393In StockIn Stock
100 mg$576In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.82%
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Product Introduction

Bioactivity
Description
9-amino-CPT (Aminocamptothecin) is an inhibitor of topoisomerase I with potent anticancer activity.
In vitro
9-amino-CPT inhibits PC-3, PC-3M, DU145, and LNCaP cells with IC50 values of 34.1, 10, 6.5, and 8.9 nM, respectively after 96 h of drug exposure [1]. In human bladder (MGH-U1), breast (MCF-7), and colon (HT-29) cancer cell lines, 9-amino-CPT cytotoxicity increases with both higher drug concentrations and longer exposure times. Minimal cell killing is also observed unless 9-amino-CPT concentrations exceed a threshold of 2.7 nM [2].
In vivo
9-amino-CPT inhibits tumor growth at the lowest oral dose (0.35 mg/kg/day), whereas higher oral doses (0.75 and 1 mg/kg/day) and s.c. administration (4 mg/kg/week) causes tumor regression [1]. 9-amino-CPT induces complete remissions in 55 % of SCID mice engrafted with human myeloid leukemia. The oral and intravenous routes are equally effective [3].
SynonymsAminocamptothecin, 9-Aminocamptothecin, 9-amino-2(S)-camptothecin
Chemical Properties
Molecular Weight363.37
FormulaC20H17N3O4
Cas No.91421-43-1
SmilesCC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4cccc(N)c4cc3Cn1c2=O
Relative Density.1.55 g/cm3 (Predicted)
ColorYellow
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 3.33 mg/mL (9.16 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7520 mL13.7601 mL27.5202 mL137.6008 mL
5 mM0.5504 mL2.7520 mL5.5040 mL27.5202 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

TopoisomeraseTopo IInhibitorinhibit9-amino-CPT9aminoCPT9-amino-2camptothecin9 amino CPT
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